Information About Generic Retrovir (Zidovudine)

What is Generic Retrovir (Zidovudine)

Working of Generic Retrovir (Zidovudine)

Generic Retrovir (Zidovudine) Dosage or Administration

Precautions for Taking Generic Retrovir (Zidovudine)

Interaction of Generic Retrovir (Zidovudine) with Other Drugs

Side effects of Generic Retrovir (Zidovudine)

Zidovudine is generic equivalent of Retrovir, it is used for In combination with other antiretroviral agents for the treatment of HIV infections; prevention of maternal-fetal HIV transmission.

What is Generic Retrovir (Zidovudine)

Generic Retrovir belong to calss Anti-infective, Antiviral. Generic Retrovir Inhibits replication of retroviruses including HIV.

Generic Retrovir (Zidovudine) Dosage or Administration

HIV Infection

Adults: PO 600 mg/day in divided doses in combination with other antiretroviral agents.

Maternal-Fetal HIV Transmission

Maternal Dosing: PO Greater than 14 wk of pregnancy-100 mg orally 5 times/day until the start of labor. During labor and delivery, administer IV zidovudine at 2 mg/kg over 1 hr followed by a continuous IV infusion of 1 mg/kg/hr until clamping of the umbilical cord. Infant Dosing: PO 2 mg/kg orally q 6 hr starting within 12 hr after birth and continuing through 6 wk of age. Infants unable to receive oral dosing may be given zidovudine IV at 1.5 mg/kg, infused over 30 min, q 6 hr.

Precautions for Taking Generic Retrovir (Zidovudine)

Pregnancy: Category C. Lactation: Undetermined. HIV-infected mothers should not breastfeed. Children: Dosing regimen not established in children less than 3 mo. Hematologic effects: Significant anemia and granulocytopenia has occurred. Use with extreme caution in patients with bone marrow compromise (Hgb less than 9.5 g/dL or granulocyte count less than 1000/mm3). Hypersensitivity: Sensitization reactions, including anaphylaxis, have occurred. Renal/Hepatic function impairment: May have greater risk of toxicity.

Interaction of Generic Retrovir (Zidovudine) with Other Drugs

Acetaminophen, nelfinavir, ribavirin, rifamycin, ritonavir, stavudine: May decrease zidovudine serum concentrations, reducing the therapeutic effect. Acyclovir: Possible increased risk of neurotoxicity (lethargy or seizure). Adriamycin, amphotericin B, dapsone, flucytosine, interferon, pentamidine, vinblastine, vincristine: May increase risk of toxicity, including nephrotoxicity, cytotoxicity, or hematologic toxicity. Aspirin, atovaquone, fluconazole, indomethacin, methadone, probenecid, trimethoprim, valproic acid: May increase serum concentration and potential toxicity of zidovudine. Doxurubicin: May antagonize the effect of zidovudine. Experimental nucleoside analogs: May affect RBC/WBC counts or function and may increase potential for hematologic toxicity. Ganciclovir: Life-threatening hematologic toxicity may occur.

Side effects of Generic Retrovir (Zidovudine)

CARDIOVASCULAR: ECG abnormality; vasodilation; syncope; cardiomyopathy; CHF. CNS: Headache; dizziness; insomnia; paresthesia; malaise; asthenia; decreased reflexes; nervousness or irritability. DERMATOLOGIC: Rash; acne. EENT: Taste perversion; hearing loss. GI: Anorexia; constipation; dyspepsia; nausea; vomiting; dysphagia; flatulence; bleeding of the gums; rectal hemorrhage; mouth ulcers; edema of the tongue; eructation; abdominal pain. HEMATOLOGIC: Anemia; granulocytopenia; pancytopenia. RESPIRATORY: Dyspnea; cough; epistaxis; pharyngitis; rhinitis; sinusitis; hoarseness. OTHER: Fever, diaphoresis; myalgia; arthralgia; muscle spasm; body odor; chills; edema of the lip; flu syndrome; hyperalgesia; abdominal/back/chest pain; hypersensitivity reaction; anemia, neutropenia (infants).