Information About Generic Reglan (Metoclopramide)

What is Generic Reglan (Metoclopramide)

Working of Generic Reglan (Metoclopramide)

Generic Reglan (Metoclopramide) Dosage or Administration

Precautions for Taking Generic Reglan (Metoclopramide)

Interaction of Generic Reglan (Metoclopramide) with Other Drugs

Side effects of Generic Reglan (Metoclopramide)

Metoclopramide is generic equivalent of Reglan, it is used for Relief of symptoms associated with acute and recurrent diabetic gastroparesis; short-term therapy of symptomatic, documented gastroesophageal reflux disease in adults who fail to respond to conventional therapy.

What is Generic Reglan (Metoclopramide)

Generic Reglan belong to calss Dopamine antagonist antiemetic agent. Generic Reglan Stimulates upper GI tract motility, resulting in accelerated gastric emptying and intestinal transit and increased resting tone of lower esophageal sphincter. Exerts antiemetic properties through antagonism of central and peripheral dopamine receptors.

Generic Reglan (Metoclopramide) Dosage or Administration

Precautions for Taking Generic Reglan (Metoclopramide)

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: Some efficacy has been demonstrated. However, methemoglobinemia has occurred in newborns. Anastomosis or closure of gut: Drug could theoretically put increased pressure on suture lines after gut anastomosis or closure. Carcinogenesis: Because the drug elevates serum prolactin concentration, use caution if administration of metoclopramide is considered in patient with previously detected breast cancer. Depression: Depression has occurred with or without history of depression. Symptoms have ranged from mild to severe and have included suicidal ideation and suicide.

Interaction of Generic Reglan (Metoclopramide) with Other Drugs

Acetaminopohen, cyclosporine, ethanol, levodopa, tetracycline

Metoclopramide may increase oral bioavailability or absorption of these drugs.

Anticholinergic, opioid analgesics, levodopa

May decrease effect of metoclopramide on gastric emptying.

Cefprozil, cimetidine, digoxin

Metoclopramide may decrease oral absorption of these drugs.

CNS depressants (eg, alcohol, anesthetics, barbiturates, opiates)

May potentiate CNS depressant effects of metoclopramide.

Succinylcholine and possibly mivacurium

By inhibiting plasma cholinesterase metoclopramide may prolong neuromuscular blocking effects such as respiratory depression and paralysis.

INCOMPAT Cephalothin, chloramphenicol, sodium bicarbonate.

Side effects of Generic Reglan (Metoclopramide)

CNS: Dizziness; drowsiness; depression; hallucinations; extrapyridal symptoms which respond rapidly to treatment with anticholinergic agents (eg, diphenhydramine IV); exacerbation of Parkinson disease; tardive dyskinesia; akathisia. DERMATOLOGIC: Transient flushing of face or upper body with high IV doses. ENDOCRINE: Hyperprolactinemia; galactorrhea; gynecomastia (in men). GI: Diarrhea. GU: Urinary frequency; incontinence; amenorrhea. HYPERSENSITIVITY: Injectable solutions may contain sodium metabisulfite, a sulfite. Sensitive individuals may experience allergic reactions (eg, anaphylaxis, bronchospasm, angioedema).
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