Information About Generic Ponstel (Mefenamic)

What is Generic Ponstel (Mefenamic)

Working of Generic Ponstel (Mefenamic)

Generic Ponstel (Mefenamic) Dosage or Administration

Precautions for Taking Generic Ponstel (Mefenamic)

Interaction of Generic Ponstel (Mefenamic) with Other Drugs

Side effects of Generic Ponstel (Mefenamic)

Mefenamic is generic equivalent of Ponstel, it is used for Relief of moderate pain lasting < 1 wk; treatment of primary dysmenorrhea. Unlabeled use(s): Treatment of sunburn, migraine (acute attack), PMS.

What is Generic Ponstel (Mefenamic)

Generic Ponstel belong to calss Analgesic/NSAID. Generic Ponstel Decreases inflammation, pain and fever, probably through inhibition of cyclooxygenase activity and prostaglandin synthesis.

Generic Ponstel (Mefenamic) Dosage or Administration

Acute Pain

ADULTS & CHILDREN > 14 YR: PO 500 mg, followed by 250 mg q 6 hr prn. Usually not used longer than 1 wk.

Primary Dysmenorrhea

ADULTS & CHILDREN > 14 YR: PO 500 mg, followed by 250 mg q 6 hr starting with onset of bleeding and associated symptoms.

Precautions for Taking Generic Ponstel (Mefenamic)

Pregnancy: Category C. Lactation: Undetermined. Children: Not recommended for children < 14 yr. Elderly: Increased risk of adverse reactions. Diarrhea: If diarrhea occurs, reduce dosage or temporarily discontinue. GI toxicity: Bleeding, ulceration, or perforation can occur at any time, with or without warning symptoms. Hypersensitivity: May occur; use with caution in aspirin-sensitive individuals because of possible cross sensitivity. Rash: Promptly discontinue if rash develops. Renal effects: Acute renal insufficiency, interstitial nephritis, hyperkalemia, hyponatremia and renal papillary necrosis may occur. Renal impairment: Lower doses may be necessary.

Interaction of Generic Ponstel (Mefenamic) with Other Drugs

Anticoagulants: Increased risk of gastric erosion and bleeding. Cyclosporine: Nephrotoxicity of both agents may be increased. Cytochrome P450: Exercise caution when coadministering mefenamic acid with drugs known to inhibit the isoenzyme 2C9. Lithium: Serum lithium levels may be increased. Methotrexate: Increased methotrexate levels. Salicylates: Additive GI toxicity.

Side effects of Generic Ponstel (Mefenamic)

CV: Edema; weight gain; CHF; altered BP; palpitations; chest pain; radycardia; tachycardia. CNS: Headache; vertigo; drowsiness; dizziness; insomnia. DERM: Rash; urticaria; purpura. EENT: Blurred vision; tinnitus; salivation; glossitis. GI: Diarrhea; dry mouth; vomiting; abdominal pain; dyspepsia; GI bleeding; ausea; constipation; flatulence. GU: Hematuria; proteinuria; dysuria; renal failure. HEMA: Decreased hematocrit; bleeding; neutropenia; leukopenia; pancytopenia; osinophilia; thrombocytopenia. HEPA: Mild elevations in liver function test results. RESP: Bronchospasm; laryngeal edema; rhinitis; dyspnea; pharyngitis; emoptysis; shortness of breath. OTHER: Autoimmune hemolytic anemia may occur if used long term.
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