Information About Generic Nolvadex (Tamoxifen)

What is Generic Nolvadex (Tamoxifen)

Working of Generic Nolvadex (Tamoxifen)

Generic Nolvadex (Tamoxifen) Dosage or Administration

Precautions for Taking Generic Nolvadex (Tamoxifen)

Interaction of Generic Nolvadex (Tamoxifen) with Other Drugs

Side effects of Generic Nolvadex (Tamoxifen)

Tamoxifen is generic equivalent of Nolvadex, it is used for Breast cancer in women, metastatic breast carcinoma in men and women, reduction in risk of breast cancer in high-risk women, lower risk of invasive breast cancer in women with ductal carcinoma in situ (DCIS). Unlabeled use(s): Mastalgia; decreasing the size and pain of gynecomastia.

What is Generic Nolvadex (Tamoxifen)

Generic Nolvadex belong to calss Antiestrogen hormone. Generic Nolvadex is a nonsteroidal agent with antiestrogenic properties. The half-life is about 14 days. Fecal excretion is the primary route of elimination.

Generic Nolvadex (Tamoxifen) Dosage or Administration

Tamoxifen Alone as Adjunct to Surgery

ADULTS: PO 20 mg/day in 1 to 2 divided doses. Duration of therapy of more than 2 yr is most effective.

Combination Chemotherapy as Adjunct to Surgery

ADULTS: PO 10 mg bid in postmenopausal women or women over 50 yr with positive axillary nodes for 5 yr.

Advanced Breast Carcinoma in Postmenopausal Women

ADULTS: PO 10 to 20 mg bid. Response to therapy should occur within 4 to 10 wk.

Prevention of Breast Cancer in High-Risk Women

ADULTS: PO 20 mg/day in 1 to 2 divided doses. Continue for 5 yr.

Precautions for Taking Generic Nolvadex (Tamoxifen)

Pregnancy: Category D. Lactation: Undetermined. Cardiovascular: Life-threatening events, including stroke and pulmonary embolism, may occur. Children: Safety and efficacy in pediatric patients not established. Disease of bone: Increased bone pain, tumor pain, and local disease flare are sometimes associated with a good tumor response shortly after starting tamoxifen, and generally subside rapidly. Hepatic effects: Changes in liver enzyme levels. Hypercalcemia: If hypercalcemia occurs, institute appropriate measures and, if severe, discontinue use. Thromboembolic effects: Thromboembolic effects including deep vein thrombosis and pulmonary embolism. Uterine effects: Endometrial changes including hyperplasia, polyps, and uterine malignancies may occur. Visual disturbances: Visual disturbances, including corneal changes, cataracts, the need for cataract surgery, decrement in color vision perception, retinal vein thrombosis, and retinopathy have occurred with use.

Interaction of Generic Nolvadex (Tamoxifen) with Other Drugs

Aminoglutethimide, phenobarbital: Tamoxifen concentrations may be reduced.

Bromocriptine: Tamoxifen concentrations may be increased.

Tacrolimus, other drugs metabolized by cytochrome P450 3A4 (eg, amitriptyline, carbamazepine, cyclosporine, lovastatin, sertraline, verapamil): Coadministration may result in reduced clearance and increased serum concentrations of these agents.

Warfarin: Increased hypoprothrombinemic effect.

Side effects of Generic Nolvadex (Tamoxifen)

CV: Peripheral edema. CNS: Headache; dizziness; depression. DERM: Rash. ENDO: Hot flashes. GI: Moderate to low potential for nausea and vomiting; food distaste. GU: Vaginal discharge, pruritus vulvae. META: Hypercalcemia. MUSC: Bone and tumor pain at initiation of therapy; soft tissue lesions can increase in size. SPEC: Retinopathy; superficial corneal opacity. OTHER: At doses of 40 mg/day, tamoxifen has an increased risk of endometrial cancer.
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