Information About Generic Nizoral (Ketoconazole)

What is Generic Nizoral (Ketoconazole)

Working of Generic Nizoral (Ketoconazole)

Generic Nizoral (Ketoconazole) Dosage or Administration

Precautions for Taking Generic Nizoral (Ketoconazole)

Interaction of Generic Nizoral (Ketoconazole) with Other Drugs

Side effects of Generic Nizoral (Ketoconazole)

Ketoconazole is generic equivalent of Nizoral, it is used for Treatment of susceptible systemic and cutaneous fungal infections.

Topical: Seborrheic dermatitis; tinea corporis; tinea cruris; tinea pedis; tinea versicolor.

What is Generic Nizoral (Ketoconazole)

Generic Nizoral belong to calss Anti-infective/antifungal. Generic Nizoral Impairs synthesis of ergosterol, allowing increased permeability in fungal cell membrane and leakage of cellular components.

Generic Nizoral (Ketoconazole) Dosage or Administration

ADULTS: PO 200 to 400 mg qd. CHILDREN > 2 YR: PO 3.3 to 6.6 mg/kg/day. Treatment may last from 1 wk to 6 mo, depending on infection. ADULTS: Topical Apply to affected and immediate surrounding area qd for 2 to 4 wk.

Precautions for Taking Generic Nizoral (Ketoconazole)

Pregnancy: Category C. Lactation: Undetermined. Children: PO: Safety and efficacy in children < 2 yr not established. Topical: Safety and efficacy not established. Anaphylaxis: Has occurred after the first dose. CN infections: Drug penetrates CSF poorly. Although high doses have sometimes been used in CNS fungal infections, this is not indicated use. Gastric acidity. Ketoconazole requires acid environment for dissolution and absorption. Hepatotoxicity: Hepatotoxicity, with rare fatalities, has occurred. Use with caution in patients receiving other potentially hepatotoxic drugs, on long-term therapy, and with a history of liver disease. Hormone levels: May lower serum testosterone or suppress adrenal corticosteroid secretion.

Interaction of Generic Nizoral (Ketoconazole) with Other Drugs

Antacids: Increased gastric pH may inhibit ketoconazole absorption; separate administration by ³ 2 hr. Benzodiazepines (eg, midazolam): Plasma levels of benzodiazepines may be increased and prolonged. Corticosteroids: Increased bioavailability and decreased clearance of corticosteroid. Cyclosporine: Increased cyclosporine concentrations. Didanosine, histamine H2-receptor antagonists (eg, cimetidine), proton pump inhibitors (eg, omeprazole): May decrease ketoconazole absorption. Dofetilide: Elevated plasma levels of dofetilide may increase the risk of life-threatening cardiac arrhythmia. Nisoldipine, protease inhibitors (eg, indinavir), tacrolimus, tolterodine: Plasma levels may be elevated by ketoconazole, increasing the risk of side effects. Rifampin: Decreased serum levels of either drug; avoid concomitant use. Theophylline: Decreased theophylline serum concentrations. Warfarin: Increased anticoagulant effect.

Side effects of Generic Nizoral (Ketoconazole)

CNS: Headache; dizziness; somnolence. DERM: Pruritus; urticaria. Topical use: Severe irritation, stinging, and itching. GI: Nausea; vomiting; abdominal pain. GU: Oligospermia (with high doses); impotence; gynecomastia. HEPA: Hepatitis.
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