Information About Generic Neurontin (Gabapentin)

What is Generic Neurontin (Gabapentin)

Working of Generic Neurontin (Gabapentin)

Generic Neurontin (Gabapentin) Dosage or Administration

Precautions for Taking Generic Neurontin (Gabapentin)

Interaction of Generic Neurontin (Gabapentin) with Other Drugs

Side effects of Generic Neurontin (Gabapentin)

Gabapentin is generic equivalent of Neurontin, it is used for Adjunctive therapy in treatment of partial seizures with or without secondary generalization in patients above 12 yr with epilepsy; adjunctive therapy for partial seizures in children 3 to 12 yr; management of postherpetic neuralgia in adults.

What is Generic Neurontin (Gabapentin)

Generic Neurontin belong to calss Anticonvulsant. Generic Neurontin Mechanism unknown; gabapentin-binding sites have been found in neocortex and hippocampus areas of the brain.

Generic Neurontin (Gabapentin) Dosage or Administration

Epilepsy

ADULTS AND CHILDREN ABOVE 12 YR: PO 900 to 1800 mg/day in divided doses tid. Initial dose: 300 mg on day 1 and titrate upward rapidly. To minimize CNS side effects, administer initial dose on day 1 at bedtime. CHILDREN 3 TO 12 YR: PO Initiate therapy at 10 to 15 mg/kg/day in divided doses (ie, 3 times/day) and titrate dose upward over a period of about 3 days to the effective dose. CHILDREN AT LEAST 5 YR: PO The effective dose is 25 to 35 mg/kg/day in divided doses (ie, 3 times/day). CHILDREN 3 TO 4 YR: PO The effective dose is 40 mg/kg/day in divided doses (ie, 3 times/day).

Precautions for Taking Generic Neurontin (Gabapentin)

Pregnancy: Category C. Lactation: Secreted in breast milk. Children: Safety and efficacy in children below 3 yr not established; safety and efficacy in management of postherpetic neuralgia in pediatric patients not established. Elderly and debilitated patients: Because of age-related renal impairment, dosage adjustment may be required. Carcinogenesis: May have carcinogenic potential. Renal impairment: Dose reduction recommended. Serious adverse effects: During clinical trials, some patients experienced status epilepticus, and 8 sudden, unexplained deaths occurred. The association of these events with gabapentin use is unclear. Withdrawal: Do not discontinue antiepileptic drugs abruptly because of possible increased seizure frequency from drug withdrawal.

Interaction of Generic Neurontin (Gabapentin) with Other Drugs

Antacids: May reduce bioavailability of gabapentin. Cimetidine: Reduces renal clearance of gabapentin.

Side effects of Generic Neurontin (Gabapentin)

CV: Hypertension. CNS: Somnolence; dizziness; ataxia; tremor; nervousness; dysarthria; amnesia; depression; abnormal thinking; twitching; abnormal coordination; vertigo; hyperkinesia; parasthesia; reflex abnormality; hostility; anxiety. DERM: Pruritus; abrasion; purpura. EENT: Diplopia; amblyopia; nystagmus; abnormal vision; gingivitis. GI: Dyspepsia; dry mouth or throat; constipation; dental abnormalities; increased appetite; anorexia; flatulence. RESP: Rhinitis; pharyngitis; coughing; pneumonia. OTHER: Fatigue; weight increase; back pain; peripheral edema; impotence; leukopenia; vasodilation; asthenia; malaise; facial edema; arthralgia.
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