Information About Generic Microzide (Hydrochlorothiazide)

What is Generic Microzide (Hydrochlorothiazide)

Working of Generic Microzide (Hydrochlorothiazide)

Generic Microzide (Hydrochlorothiazide) Dosage or Administration

Precautions for Taking Generic Microzide (Hydrochlorothiazide)

Interaction of Generic Microzide (Hydrochlorothiazide) with Other Drugs

Side effects of Generic Microzide (Hydrochlorothiazide)

Hydrochlorothiazide is generic equivalent of Microzide, it is used for Adjunctive therapy for edema associated with CHF, hepatic cirrhosis, renal dysfunction, and corticosteroid and estrogen therapy; treatment of hypertension. Unlabeled use(s): Prevention of formation and precurrence of calcium nephrolithiasis; therapy for nephrogenic diabetes insipidus.

What is Generic Microzide (Hydrochlorothiazide)

Generic Microzide belong to calss Thiazide diuretic. Generic Microzide Enhances excretion of sodium, chloride, and water by interfering with transport of sodium ions across renal tubular epithelium.

Generic Microzide (Hydrochlorothiazide) Dosage or Administration

Edema

ADULTS: PO 25 to 100 mg/day. Rarely patients may require 200 mg/day.

Hypertension

ADULTS: PO 25 to 50 mg/day as single dose or 2 divided doses. INFANTS < 6 MO: PO Up to 3.3 mg/kg/day in 2 doses. INFANTS 6 MO TO 2 YR: PO 12.5 to 37.5 mg daily in 2 doses. CHILDREN 2 TO 12 YR: PO 37.5 to 100 mg daily in 2 doses.

Precautions for Taking Generic Microzide (Hydrochlorothiazide)

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: Safety and efficacy have not been established in controlled clinical studies. Hepatic impairment: Minor alterations of fluid and electrolyte balance may precipitate hepatic coma; use drug with caution. Hypersensitivity: May occur in patients with or without history of allergy or bronchial asthma; cross-sensitivity with sulfonamides may also occur. Lupus erythematosus: Exacerbation or activation may occur. Postsympathectomy patients: Drug may enhance antihypertensive effects. Renal impairment: Drug may precipitate azotemia; use drug with caution.

Interaction of Generic Microzide (Hydrochlorothiazide) with Other Drugs

Bile acid sequestrants: May reduce thiazide absorption; give thiazide ³ 2 hr before resin. Diazoxide: May cause hyperglycemia. Digitalis glycosides: Diuretic-induced hypokalemia and hypomagnesemia may precipitate digitalis-induced arrhythmias. Lithium: May decrease renal excretion of lithium. Loop diuretics: Synergistic effects may result in profound diuresis and serious electrolyte abnormalities. Sulfonylureas, insulin: May decrease hypoglycemic effect of sulfonylureas. May need to increase dosage of sulfonylureas or insulin.

Side effects of Generic Microzide (Hydrochlorothiazide)

CV: Orthostatic hypotension. CNS: Dizziness; lightheadedness; vertigo; headache; paresthesias; weakness; restlessness; insomnia. DERM: Purpura; photosensitivity; rash; urticaria; necrotizing angitis, vasculitis, cutaneous vasculitis; alopecia; exfoliative dermatitis; toxic epidermal necrolysis; erythema multiforme; Stevens-Johnson syndrome. EENT: Blurred vision; xanthopsia (yellow vision). GI: Anorexia; gastric irritation; nausea; vomiting; abdominal pain or cramping; bloating; diarrhea; constipation; pancreatitis; sialadenitis. GU: Impotence; reduced libido; interstitial nephritis. HEMA: Leukopenia; thrombocytopenia; agranulocytosis; aplastic or hypoplastic anemia; hemolytic anemia. HEPA: Jaundice. META: Hyperglycemia; glycosuria; hyperuricemia; electrolyte imbalance. RESP: Respiratory distress; pneumonitis; pulmonary edema. OTHER: Muscle cramp or spasm; fever; anaphylactic reactions.