Information About Generic Lopressor (Metoprolol)

What is Generic Lopressor (Metoprolol)

Working of Generic Lopressor (Metoprolol)

Generic Lopressor (Metoprolol) Dosage or Administration

Precautions for Taking Generic Lopressor (Metoprolol)

Interaction of Generic Lopressor (Metoprolol) with Other Drugs

Side effects of Generic Lopressor (Metoprolol)

Metoprolol is generic equivalent of Lopressor, it is used alone or in combination with other antihypertensive agents, for management of hypertension, long-term management of angina pectoris, myocardial infarction (immediate-release tablets and injection).

What is Generic Lopressor (Metoprolol)

Generic Lopressor belong to calss Beta-adrenergic blocker. Generic Metoprolol Blocks beta receptors, primarily affecting cardiovascular system (decreases heart rate, decreases contractility, decreases BP) and lungs (promotes bronchospasm).

Generic Lopressor (Metoprolol) Dosage or Administration

Hypertension

ADULTS: PO 100 mg/day in single or divided doses initially; maintenance: 100–450 mg/day.

Angina

ADULTS: PO 100 mg/day in 2 divided doses initially; maintenance: 100–400 mg/day.

Myocardial Infarction

ADULTS: IV bolus injection 5 mg slowly; may repeat every 2 min up to total of 15 mg. If tolerated, give PO 50 mg q 6 hr beginning 15 min after last IV dose; continue for 48 hr followed by PO 100 mg bid for 1–3 mo. If patient is intolerant of full IV dose, give PO 25–50 mg q 6 hr starting 15 min after last IV dose.

Precautions for Taking Generic Lopressor (Metoprolol)

Pregnancy: Category C. Lactation: Excreted in breast milk. Children: Safety and efficacy not established. Anaphylaxis: Deaths have occurred; aggressive therapy may be required. AV block: Slows AV conduction and may cause heart block. Bradycardia: Metoprolol decreases heart rate in most patients. Congestive heart failure: Administer cautiously in CHF patients controlled by digitalis and diuretics. Notify physician at first sign or symptom of CHF or of unexplained respiratory symptoms in any patient.

Interaction of Generic Lopressor (Metoprolol) with Other Drugs

Barbiturates: Bioavailability of metoprolol may decrease. Cimetidine: May increase metoprolol levels. Clonidine: May enhance or reverse antihypertensive effect; potentially life-threatening situations may occur, especially on abrupt withdrawal of clonidine. Hydralazine: Serum levels of both drugs may increase. Lidocaine: Lidocaine levels may increase, leading to toxicity. NSAIDs: Some agents may impair antihypertensive effect. Prazosin: Orthostatic hypotension may increase. Propafenone, quinidine, thioamines: Effects of metoprolol may increase. Rifampin: May decrease effects of metoprolol. Verapamil: Effects of both drugs may be increased.

Side effects of Generic Lopressor (Metoprolol)

CV: Hypotension; edema; flushing; bradycardia. CNS: Headache; fatigue; dizziness; depression; lethargy; drowsiness; forgetfulness; leepiness; vertigo; paresthesias. DERM: Rash; facial erythema; alopecia; urticaria; pruritus. EENT: Dry eyes; visual disturbances. GI: Nausea; vomiting; diarrhea. GU: Impotence; urinary retention; difficulty with urination. RESP: Bronchospasm; dyspnea; wheezing. OTHER: Increased hypoglycemic response to insulin; may mask hypoglycemic signs; uscle cramps; asthenia; systemic lupus erythematosus.