Information About Generic Lioresal (Baclofen)

What is Generic Lioresal (Baclofen)

Working of Generic Lioresal (Baclofen)

Generic Lioresal (Baclofen) Dosage or Administration

Precautions for Taking Generic Lioresal (Baclofen)

Interaction of Generic Lioresal (Baclofen) with Other Drugs

Side effects of Generic Lioresal (Baclofen)

Baclofen is generic equivalent of Lioresal, it is used for Treatment of reversible spasticity resulting from multiple sclerosis. May be of some value in patients with spinal cord injuries and other spinal cord diseases. Intrathecal: Treatment of severe spasticity of spinal cord origin in patients who are unresponsive to or cannot tolerate oral baclofen therapy. Used intrathecally in single bolus test doses; chronic use requires implantable pump. Unlabeled use(s): Oral: Therapy for trigeminal neuralgia (tic douloureux); tardive dyskinesia. Intrathecal: Cerebral palsy spasticity in children.

What is Generic Lioresal (Baclofen)

Generic Lioresal belong to calss Skeletal muscle relaxant/Centrally acting. Generic Lioresal May inhibit transmission of reflexes at spinal level, possibly by action (hyperpolarization) at primary afferent fiber terminals resulting in relief of muscle spasticity; has CNS depressant properties.

Generic Lioresal (Baclofen) Dosage or Administration

ADULTS: Initial dose: PO 5 mg tid; may be increased by 5 mg/dose q 3 days prn to max 80 mg/day (20 mg qid). Intrathecal Refer to manufacturer's manual for implantable pump.

Precautions for Taking Generic Lioresal (Baclofen)

Pregnancy: Category C. Lactation: Excreted in breast milk. Children: Safety of oral baclofen in children less than 12 yr and of intrathecal baclofen in children less than 4 yr has not been established. Abrupt discontinuation: Abrupt discontinuation of intrathecal baclofen has resulted in sequelae that include high fever, altered mental status, exaggerated rebound spasticity, and muscle rigidity, which in rare cases has advanced to rhabdomyolysis, multiple organ system failure, and death. Intrathecal use: Only specially trained personnel should administer drug intrathecally because of potentially life-threatening CNS depression, cardiovascular collapse, or respiratory failure. Epilepsy and psychotic disorders: Use with caution because of potential exacerbations. Fatalities: Fatalities occurred in premarketing trials of intrathecal baclofen; role of baclofen in these deaths is unknown. Infection: Patients should be infection-free before screening trial with baclofen injection. Renal impairment: Administer with caution. Dosage reduction may be necessary. Stroke: Drug has not significantly benefited patients with stroke; these patients also have poor drug tolerance.

Interaction of Generic Lioresal (Baclofen) with Other Drugs

CNS depressants: May cause increased sedative effects. Morphine (epidural): May cause hypotension and dyspnea.

Side effects of Generic Lioresal (Baclofen)

CV: Hypotension; palpitations; chest pain. CNS: Drowsiness; weakness in lower extremities; dizziness; seizures; headache; numbness; euphoria; depression; confusion; lethargy; insomnia. DERM: Pruritus; rash. EENT: Tinnitus; blurred vision; taste disorder; nasal congestion. GI: Nausea; vomiting; dry mouth; constipation; diarrhea; abdominal pain; anorexia. GU: Urinary frequency; enuresis; dysuria; impotence. RESP: Dyspnea. OTHER: Hypotonia; slurred speech; muscle pain; ankle edema; excessive perspiration; weight gain.
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