Information About Generic Indocin (Indomethacin)

What is Generic Indocin (Indomethacin)

Working of Generic Indocin (Indomethacin)

Generic Indocin (Indomethacin) Dosage or Administration

Precautions for Taking Generic Indocin (Indomethacin)

Interaction of Generic Indocin (Indomethacin) with Other Drugs

Side effects of Generic Indocin (Indomethacin)

Indomethacin is generic equivalent of Indocin, it is used for Indomethacin: Symptomatic treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gouty arthritis, acute painful shoulder. Indomethacin sodium trihydrate (IV): Closure of patent ductus arteriosus. Unlabeled use(s): Treatment of primary dysmenorrhea; migraine prophylaxis; treatment of cluster headache, polyhydramnios, sunburn; cystoid macular edema.

What is Generic Indocin (Indomethacin)

Generic Indocin belong to calss Analgesic/NSAID. Generic Indocin Decreases inflammation, pain, and fever, probably through inhibition of cyclooxygenase activity and prostaglandin synthesis.

Generic Indocin (Indomethacin) Dosage or Administration

Rheumatoid Arthritis, Osteoarthritis, Ankylosing Spondylitis

ADULTS: PO 25 mg bid or tid up to maximum of 200 mg/day (or 75 mg sustained release form 1 to 2 times daily)

Gouty Arthritis

ADULTS: PO/PR 50 mg tid; do not use sustained-release form.

Acute Painful Shoulder

ADULTS: PO 75 to 150 mg/day in divided doses for 7 to 14 days.

Patent Ductus Arteriosus

IV 3 doses total. INFANTS < 2 DAYS OLD: IV 0.2 mg/kg followed by 2 doses of 0.1 mg/kg 12 to 24 hr apart. INFANTS 2 TO 7 DAYS OLD: 3 doses of 0.2 mg/kg separated by 12 to 24 hr. INFANTS > 7 DAYS OLD: 0.2 mg/kg followed by 2 doses of 0.25 mg/kg separated by 12 to 24 hr.

Precautions for Taking Generic Indocin (Indomethacin)

Pregnancy: Safety not established. Lactation: Undetermined. Children: Safety and efficacy not established in children < 14 yr, except use of IV form in infants. CNS effects: May aggravate depression or other psychiatric disorders, epilepsy, or Parkinsonism; use with caution. Electrolyte imbalance: IV indomethacin may suppress water excretion to greater extent than sodium excretion; monitor electrolytes and renal function. GI effects: Usually not given to patients with active GI lesions or history of recurrent GI lesions. Renal impairment: NSAIDs may worsen preexisting renal dysfunction.

Interaction of Generic Indocin (Indomethacin) with Other Drugs

Anticoagulants: May increase risk of gastric erosion and bleeding. Beta-blockers, ACE inhibitors: Antihypertensive effects may be decreased. Diflunisal: Diflunisal may decrease the renal clearance and significantly increase indomethacin plasma concentrations that may produce toxicity. Digoxin: May increase digoxin levels. Lithium: May decrease lithium clearance. Loop diuretics: May decrease diuretic effects. Methotrexate: May increase methotrexate levels. Penicillamine: Indomethacin may increase the bioavailability of pencillamine. Potassium-sparing diuretics: Effects of potassium-diuretics may be decreased. Concomitant administration may increase serum potassium levels. Sympathomimetics: Indomethacin and phenylpropanolamine coadministration may result in increased blood pressure.

Side effects of Generic Indocin (Indomethacin)

CV: Peripheral edema; water retention; worsening or precipitation of CHF. CNS: Dizziness; headache; drowsiness; confusion. EENT: Visual disturbances; tinnitus. GI: Gastric distress; occult blood loss; nausea; diarrhea; vomiting; ulceration; perforation. GU: Acute renal insufficiency; interstitial nephritis; hyponatremia; renal papillary necrosis. HEMA: Leukopenia. META: Hyperuricemia; hyperkalemia.
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