Information About Generic Inderal (Propranolol HCl)

What is Generic Inderal (Propranolol HCl)

Working of Generic Inderal (Propranolol HCl)

Generic Inderal (Propranolol HCl) Dosage or Administration

Precautions for Taking Generic Inderal (Propranolol HCl)

Interaction of Generic Inderal (Propranolol HCl) with Other Drugs

Side effects of Generic Inderal (Propranolol HCl)

Propranolol HCl is generic equivalent of Inderal, it is used for Treatment of hypertension; angina pectoris; hypertrophic subaortic stenosis; MI; pheochromocytoma; migraine prophylaxis; essential tremor; some ventricular and supraventricular arrhythmias. Unlabeled use(s): Treatment of alcohol withdrawal syndrome; esophageal varices rebleeding; anxiety; thyrotoxicosis symptoms.

What is Generic Inderal (Propranolol HCl)

Generic Inderal belong to calss Beta-adrenergic blocker. Generic Inderal Blocks beta receptors, primarily affecting the cardiovascular system (decreased heartrate, decreased cardiac contractility and decreased BP) and lungs (promotes bronchospasm).

Generic Inderal (Propranolol HCl) Dosage or Administration

Hypertension

ADULTS: PO Initial dose: 40 mg bid initially or 80 mg sustained-release medication/day; titrate to response. Maintenance: 120 to 240 mg/day in 2 to 3 divided doses or 120 to 160 mg/day sustained-release medication. Do not exceed 640 mg/day. CHILDREN: PO 0.5 mg/kg bid; titrate q 3 to 5 days to maximum dose of 1 mg/kg bid.

Precautions for Taking Generic Inderal (Propranolol HCl)

Pregnancy: Category C. Lactation: Excreted in breast milk. Children: Safety and efficacy not established. IV use is not recommended, but oral propranolol has been used. Abrupt withdrawal: A beta-blocker withdrawal syndrome (eg, hypertension, tachycardia, anxiety, angina, MI) may occur 1 to 2 weeks after sudden discontinuation of systemic beta blockers. If possible, gradually withdraw therapy over 1 to 2 weeks. Anaphylaxis: Deaths have occurred; aggressive therapy may be required. CHF: Should be administered cautiously in patients whose CHF is controlled by digitalis and diuretics. Diabetes mellitus: May mask symptoms of hypoglycemia (eg, tachycardia, BP changes). May potentiate insulin-induced hypoglycemia. Nonallergic bronchospastic diseases: Give drug with caution in patients with bronchospastic diseases. Peripheral vascular disease: May precipitate or aggravate symptoms of arterial insufficiency. Renal/Hepatic impairment: Dose should be reduced. Thyrotoxicosis: May mask clinical signs (eg, tachycardia) of developing or continuing hyperthyroidism. Abrupt withdrawal may exacerbate symptoms of hyperthyroidism, including thyroid storm. Wolff-Parkinson-White syndrome: In several cases, tachycardia was replaced by severe bradycardia requiring a demand pacemaker.

Interaction of Generic Inderal (Propranolol HCl) with Other Drugs

Barbiturates: Decreased bioavailability of propranolol. Cimetidine: Increased propranolol levels. Clonidine: Attenuation or reversal of antihypertensive effect; potentially life-threatening increases in BP, especially on withdrawal. Epinephrine: Initial hypertensive episode followed by bradycardia. Ergot alkaloids: Peripheral ischemia, manifested by cold extremities and possible gangrene. Hydralazine: Increased serum levels of both drugs. Insulin: Prolonged hypoglycemia with masking of symptoms. Lidocaine: Increased lidocaine levels, leading to toxicity. NSAIDs: Some agents may impair antihypertensive effect. Phenothiazines: Increased effects of either drug. Prazosin: Increased orthostatic hypotension. Propafenone, quinidine, thioamines: Increased effects of propranolol. Rifampin: Decreased effects of propranolol. Theophylline: Reduces elimination of theophylline; pharmacologic antagonism. Verapamil: Increased effects of both drugs.

Side effects of Generic Inderal (Propranolol HCl)

CV: Bradycardia; hypotension; CHF; atrioventricular (AV) block; worsening angina; torsades de pointes; edema; peripheral ischemia. CNS: Depression; tiredness; fatigue; lethargy; sleep disturbances;. bizarre dreams; short-term memory loss; dizziness. DERM: Rash; pruritus. EENT: Dry eyes; visual disturbances. GI: Dyspepsia; nausea; vomiting; diarrhea; dry mouth. GU: Impotence; urinary retention; difficulty with urination. HEMA: Agranulocytosis. HEPA: Elevated liver enzymes. META: Hyperglycemia; hypoglycemia. RESP: Wheezing; dyspnea; bronchospasm; difficulty breathing. OTHER: Increased sensitivity to cold (Raynaud's phenomenon); psoriasis-like eruptions; skin necrosis; systemic lupus erythematosus; decreased exercise tolerance.