Information About Generic Imuran (Azathioprine)

What is Generic Imuran (Azathioprine)

Working of Generic Imuran (Azathioprine)

Generic Imuran (Azathioprine) Dosage or Administration

Precautions for Taking Generic Imuran (Azathioprine)

Interaction of Generic Imuran (Azathioprine) with Other Drugs

Side effects of Generic Imuran (Azathioprine)

Azathioprine is generic equivalent of Imuran, it is used for Adjunct for prevention of rejection in renal homotransplantation; treatment in adults for severe, active, erosive rheumatoid arthritis not responsive to conventional management. Unlabeled use(s): Treatment of chronic ulcerative colitis, Crohn's disease, myasthenia gravis and Behcet's syndrome.

What is Generic Imuran (Azathioprine)

Generic Imuran belong to calss Immunosuppressive. Generic Imuran Suppresses cell-mediated hypersensitivities; alters antibody production and may reduce inflammation.

Generic Imuran (Azathioprine) Dosage or Administration

Renal Transplantation

ADULTS & CHILDREN: IV/PO Initiate with 3 to 5 mg/kg/day as single daily dose. Maintenance levels are 1 to 3 mg/kg/day.

Rheumatoid Arthritis

ADULTS: PO Initial dose is 1 mg/kg given as single dose or twice daily. Dose is increased by 0.5 mg/kg/day at 6 to 8 wk, then every 4 wk if there are no serious toxicities and if initial response is unsatisfactory. Max dose is 2.5 mg/kg/day. IV Reserved for patients unable to tolerate oral medications.

Precautions for Taking Generic Imuran (Azathioprine)

Pregnancy: Category D. Lactation: Excreted in breast milk. Children: Safety and efficacy not established. Carcinogenesis/mutagenesis: Chronic immunosuppression with azathioprine increases risk of neoplasia. Patients with rheumatoid arthritis previously treated with alkylating agents (eg, cyclophosphamide, chlorambucil, melphalan) may have prohibitive risk of neoplasia. GI toxicity: Hypersensitivity reaction with severe nausea and vomiting may occur. Frequency of gastric disturbances can be reduced by giving in divided doses or after meals. Hematologic effects: Severe hematologic toxicities may occur; monitor blood counts. Hepatoxicity: Occurs primarily in allograft recipients. Rare but life-threatening hepatic veno-occlusive disease has occurred in transplant patients; monitor liver function tests. Superinfection: Serious fungal, viral, bacterial and protozoal infections may develop in patients on long-term immunosuppression.

Interaction of Generic Imuran (Azathioprine) with Other Drugs

Allopurinol: Decreases metabolism of azathioprine. Dose of azathioprine is reduced to approximately one-third to one-fourth usual dose when used concomitantly. Nondepolarizing muscle relaxants (eg, tubocurarine, pancuronium): Azathioprine may resist or reverse neuromuscular blockade.

Side effects of Generic Imuran (Azathioprine)

DERM: Rash. GI: Nausea; vomiting. HEMA: Leukopenia; thrombocytopenia; macrocytic anemia; bleeding; selective erythrocyte aplasia. OTHER: Serious infections; neoplasias.
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