Information About Generic Imitrex (Sumatriptan Succinate)

What is Generic Imitrex (Sumatriptan Succinate)

Working of Generic Imitrex (Sumatriptan Succinate)

Generic Imitrex (Sumatriptan Succinate) Dosage or Administration

Precautions for Taking Generic Imitrex (Sumatriptan Succinate)

Interaction of Generic Imitrex (Sumatriptan Succinate) with Other Drugs

Side effects of Generic Imitrex (Sumatriptan Succinate)

Sumatriptan Succinate is generic equivalent of Imitrex, it is used for Short-term treatment of migraine attacks with/without aura; treatment of acute cluster headaches (injection only).

What is Generic Imitrex (Sumatriptan Succinate)

Generic Imitrex belong to calss Analgesic, Migraine. Generic Imitrex Selective agonist for vascular serotonin (5-HT) receptor subtype, causing vasoconstriction of cranial arteries.

Generic Imitrex (Sumatriptan Succinate) Dosage or Administration

ADULTS: PO Recommended dose is £ 100 mg taken with fluids. Doses of 100 mg have not been proven to provide a greater effect than 50 mg. If headache returns, additional doses may be taken at intervals of ³ 2 hr up to a max of 200 mg/day. If headache returns following an initial dose with the injection, additional doses of single tablets (up to 100 mg/day) may be given with an interval of ³ 2 hr between tablet doses. SC Administer as soon as symptoms appear. Max single adult dose is 6 mg. Max dose per 24 hr is two 6 mg injections separated by ³ 1 hr. Available in autoinjection prefilled syringe devices that deliver 6 mg for easy use; however, lower doses should be used in patients who have side effects at usual dose.

Precautions for Taking Generic Imitrex (Sumatriptan Succinate)

Pregnancy: Category C. Lactation: Excreted in breast milk. Children: Safety and efficacy not established. Elderly: Safety and efficacy in patients > 65 yr not thoroughly evaluated. Cardiac Events/Vasoconstriction: Serious coronary events, though extremely rare, can occur after sumatriptan use. Administer first dose in health care provider’s office to patients at possible risk of unrecognized coronary disease. If symptoms consistent with angina occur, conduct ECG evaluation for ischemic changes. May cause coronary vasospasm in patients with history of CAD. Rare reports of major arrhythmias and angina symptoms. Hepatic or Renal Function Impairment: Use caution.

Interaction of Generic Imitrex (Sumatriptan Succinate) with Other Drugs

5-HT1 Agonists (eg, Sumatriptan)

Increased risk of vasospastic reactions; therefore, coadministration of two 5-HT1 agonists within 24 hr of each other is contraindicated.

Ergot-Containing Drugs

May cause additive prolonged vasospastic reactions. Avoid use within 24 hr of each other.

MAOIs

Use of sumatriptan with MAOIs or within 14 days following discontinuation of an MAOI is contraindicated.

Selective Serotonin Reuptake Inhibitors (Citalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline)

Weakness, hyperreflexia, and incoordination have been reported rarely.

Sibutramine

Serotonin syndrome, including CNS irritablilty, motor weakness, shivering, myoclonus, and altered consciousness may occur.

Side effects of Generic Imitrex (Sumatriptan Succinate)

CARDIOVASCULAR: Hypertension; hypotension; bradycardia; tachycardia; palpitations; pulsating sensations; various transient ECG changes; syncope; arrhythmia; angina; coronary vasospasm in patients with history of CAD. CNS: Dizziness; vertigo; drowsiness; sedation; headache; anxiety; malaise; fatigue. EENT: Eye irritation; vision alterations; photophobia; lacrimation; throat or mouth discomfort; nasal cavity or sinus discomfort. GI: Abdominal discomfort; dysphagia; abdominal discomfort, dysphagia, mouth/tongue disorder (eg, burning of tongue, numbness of tongue, dry mouth) (intranasal). OTHER: Tingling; warm or hot sensation; burning sensation; feeling of heaviness; numbness; feeling strange; tight feeling in head; cold sensation; weakness; neck pain or stiffness; myalgia; muscle cramp; tightness or pressure in chest; injection site reaction; flushing; sweating; abnormalities in LFTs; hearing disturbances, ear infection, eye irritation, visual disturbances (intranasal).
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