Information About Generic Glucotrol (Glipizide)

What is Generic Glucotrol (Glipizide)

Working of Generic Glucotrol (Glipizide)

Generic Glucotrol (Glipizide) Dosage or Administration

Precautions for Taking Generic Glucotrol (Glipizide)

Interaction of Generic Glucotrol (Glipizide) with Other Drugs

Side effects of Generic Glucotrol (Glipizide)

Glipizide is generic equivalent of Glucotrol, it is used for Adjunct to diet to lower blood glucose in patients with non-insulin-dependent diabetes mellitus (type II) whose hyperglycemia cannot be controlled by diet alone.

What is Generic Glucotrol (Glipizide)

Generic Glucotrol belong to calss Antidiabetic. Generic Glucotrol Decreases blood glucose by stimulating insulin release from pancreas and by increasing tissue sensitivity to insulin.

Generic Glucotrol (Glipizide) Dosage or Administration

ADULTS: PO 5 mg/day 30 min before breakfast. Dose should be adjusted in 2.5 to 5 mg/day increments based on blood glucose response. Divided doses may be given (maximum single daily dose 15 mg; maximum total daily dose 40 mg). ELDERLY OR PATIENTS WITH LIVER DISEASE: PO 2.5 mg/day initially.

Precautions for Taking Generic Glucotrol (Glipizide)

Pregnancy: Category C. Insulin is recommended to maintain blood glucose levels during pregnancy. Prolonged severe neonatal hypoglycemia can occur if sulfonylureas are administered at time of delivery. Lactation: Undetermined. Children: Safety and efficacy not established. Elderly and debilitated patients: Elderly and debilitated patients are particularly susceptible to hypoglycemic action. Hypoglycemia may be difficult to recognize in elderly. Hepatic and renal impairment: Use drug with caution and monitor liver and renal function frequently.

Interaction of Generic Glucotrol (Glipizide) with Other Drugs

Alcohol: Produces disulfiram-like reactions (facial flushing, headache, breathlessness). Androgens, chloramphenicol, clofibrate, fenfluramine, fluconazole, gemfibrozil, histamine H2 antagonists, magnesium salts, methyldopa, monoamine oxidase, oral anticoagulants, phenylbutazone, probenecid, salicylates, sulfinpyrazone, sulfonamides, tricyclic antidepressants, urinary acidifiers: Hypoglycemic effects may be increased. Betablockers, cholestyramine, diazoxide, hydantoins, rifampin, thiazide diuretics, urinary alkalinizers: May decrease hypoglycemic effect. Food: Absorption is delayed when taken with food. Give drug » 30 min before meal.

Side effects of Generic Glucotrol (Glipizide)

CV: May have increased risk of cardiovascular mortality when compared with patients treated with diet alone. CNS: Dizziness; vertigo. DERM: Allergic skin reactions; eczema; pruritus; erythema; urticaria; morbilliform or maculopapular eruptions; lichenoid reactions; photosensitivity. EENT: Tinnitus. GI: GI disturbances (eg, nausea, epigastric fullness, heartburn); diarrhea. GU: Mild diuresis; elevated BUN and creatinine. HEPA: Cholestatic jaundice; elevated liver function test results. HEMA: Leukopenia; thrombocytopenia; aplastic anemia; agranulocytosis; hemolytic anemia; pancytopenia; hepatic porphyria. META: Hypoglycemia. OTHER: Disulfiram-like reaction; weakness; paresthesia; fatigue; malaise.
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