Information About Generic Glucophage (Metformin)

What is Generic Glucophage (Metformin)

Working of Generic Glucophage (Metformin)

Generic Glucophage (Metformin) Dosage or Administration

Precautions for Taking Generic Glucophage (Metformin)

Interaction of Generic Glucophage (Metformin) with Other Drugs

Side effects of Generic Glucophage (Metformin)

Metformin is generic equivalent of Glucophage, it is used for Adjunct to diet to lower blood glucose in patients with type 2 diabetes mellitus whose hyperglycemia cannot be controlled by diet alone.

What is Generic Glucophage (Metformin)

Generic Glucophage belong to calss Antidiabetic, Biguanide. Generic Glucophage Decreases blood glucose by decreasing hepatic glucose production. May also decrease intestinal absorption of glucose and increase response to insulin.

Generic Glucophage (Metformin) Dosage or Administration

ADULTS: Initial dose: PO 500 mg bid, increase by 500 mg q wk (max, 2500 mg/day in divided doses).

ADULTS: Initial dose: PO 850 mg qd, increase by 850 mg q 2 wk (max, 2550 mg/day in divided doses).

ADULTS: Glucophage XR Initial dose: PO 500 mg qd with evening meal, increase by 500 mg q wk (max, 2000 mg once daily). If higher doses of metformin are required, administer at total daily dose up to 2500 mg in divided daily doses as described above.

Precautions for Taking Generic Glucophage (Metformin)

Pregnancy: Category B. Insulin is recommended to maintain blood glucose levels during pregnancy. Lactation: Undetermined. Children: Safety and efficacy not established. Elderly: Use with caution. Maximum doses are generally not used because of age-related decreases in renal function. Lactic Acidosis: Can occur and be fatal in » 50% of cases, as a result of metformin accumulation (eg, renal impairment) or with pathophysiologic conditions associated with tissue hypoperfusion and hypoxia. The risk of lactic acidosis increases with the degree of renal dysfunction and the patient’s age. Renal Impairment: Decreased renal function results in decreased renal clearance and prolongation of the metformin half-life. Concomitant medications that affect renal function, result in significant hemodynamic changes or interfere with disposition of metformin (eg, cationic drugs eliminated by renal tubular secretion) should be used with caution. Hepatic Disease: Avoid metformin in patients with clinical or laboratory evidence of hepatic disease. GI Symptoms: GI symptoms occurring after a patient is stabilized on metformin are unlikely to be drug related but could be because of lactic acidosis or other serious disease. Iodinated Contrast Material: Withhold metformin for ³ 48 hr before parenteral contrast studies with iodinated materials. Reinstitute therapy 48 hr after the study and after renal function has been determined to be normal.

Interaction of Generic Glucophage (Metformin) with Other Drugs

Alcohol

Potentiates effect of metformin on lactate metabolism.

Cationic Drugs (eg, Amiloride, Digoxin, Quinidine)

May increase metformin serum concentration by competing for tubular secretion.

Cimetidine

Increases metformin serum concentration.

Furosemide

May increase metformin serum concentration; metformin may reduce furosemide serum concentration.

Iodinated Contrast Material

May cause acute renal failure and has been associated with lactic acidosis in patients receiving metformin.

Nifedipine

Increases metformin serum concentration.

Side effects of Generic Glucophage (Metformin)

EENT: Unpleasant/metallic taste. GI: Diarrhea; nausea; vomiting; abdominal bloating; flatulence; anorexia. METABOLIC: Lactic acidosis. OTHER: Subnormal vitamin B12 levels.
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