Information About Generic Flagyl (Metronidazole)

What is Generic Flagyl (Metronidazole)

Working of Generic Flagyl (Metronidazole)

Generic Flagyl (Metronidazole) Dosage or Administration

Precautions for Taking Generic Flagyl (Metronidazole)

Interaction of Generic Flagyl (Metronidazole) with Other Drugs

Side effects of Generic Flagyl (Metronidazole)

Metronidazole is generic equivalent of Flagyl, it is used for Treatment of serious infections caused by susceptible anaerobic bacteria; prophylaxis of postoperative infection in patients undergoing colorectal surgery; treatment of amebiasis; treatment of trichomoniasis and asymptomatic partners of infected patients; bacterial vaginosis.

Topical: Treatment of inflammatory papules, pustules, and erythema of acne rosacea.

Vaginal: Treatment of bacterial vaginosis.

Treatment of hepatic encephalopathy, Crohn disease, antibiotic-associated pseudomembranous colitis, Helicobacter pylori infections.

What is Generic Flagyl (Metronidazole)

Generic Flagyl belong to calss Anti-infective. Generic Flagyl Enters bacterial or protozoal cell and impairs synthesis of DNA, resulting in cell death.

Generic Flagyl (Metronidazole) Dosage or Administration

Anaerobic Bacterial Infections

ADULTS: IV 15 mg/kg loading dose infused over 1 hr (approximately 1 g for a 70 kg adult); then 7.5 mg/kg infused over 1 hr q 6 hr (approximately 500 mg for a 70-mg adult). Do not exceed 4 g in 24 hr. May follow with similar oral dose. For prophylaxis, loading dose is to be completed 1 hr before surgery, followed by maintenance dose 6 and 12 hr later.

Bacterial Vaginosis

ADULTS: PO 750 mg (Flagyl ER) once daily for 7 consecutive days. Vaginal 1 applicatorful (approximately 37.5 mg metronidazole) intravaginally bid for 5 days.

Precautions for Taking Generic Flagyl (Metronidazole)

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: Safety and efficacy not established, except for amebiasis. Elderly: Monitoring serum levels may be necessary for proper dosing. Hepatic Impairment: Patients with severe hepatic disease metabolize drug slowly; use caution and lower dose. Neurologic Effects: Seizures and peripheral neuropathy have occurred. Use extra caution with prolonged use, high doses, or history of CNS disease.

Interaction of Generic Flagyl (Metronidazole) with Other Drugs

Anticoagulants: Anticoagulant effect may be increased.

Barbiturates: Therapeutic failure of metronidazole may occur.

Disulfiram: Concurrent use may result in acute psychosis or confusional state. Metronidazole should not be given to patients who have taken disulfiram within last 2 wk.

Ethanol: Disulfiram-like reaction including flushing, palpitations, tachycardia, nausea, and vomiting may occur with concurrent use.

Do not use aluminum-containing equipment with metronidazole because solution will turn orange/rust color.

Side effects of Generic Flagyl (Metronidazole)

CARDIOVASCULAR: Flattening of T-wave. CNS: Seizures; peripheral neuropathy; dizziness; vertigo; incoordination; ataxia; confusion; depression; insomnia; syncope. DERMATOLOGIC: Thrombophlebitis; urticaria; erythematous rash; flushing. EENT: Metallic taste; glossitis; stomatitis. GI: Nausea; anorexia; vomiting; diarrhea; epigastric distress; cramps; proctitis; pseudomembranous colitis. GU: Darkening of urine; dysuria; cystitis; polyuria; incontinence; vaginal Candida proliferation; decreased libido. HEMATOLOGIC: Mild leukopenia. OTHER: Hypersensitivity reactions including dermatologic reactions, nasal congestion, dry mouth or vagina, and fever; fleeting joint pain; pancreatitis. Topical or vaginal use may cause similar adverse effects. After prolonged IV use, thrombophlebitis may occur.
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