Information About Generic Elavil (Amitriptyline HCl)

What is Generic Elavil (Amitriptyline HCl)

Working of Generic Elavil (Amitriptyline HCl)

Generic Elavil (Amitriptyline HCl) Dosage or Administration

Precautions for Taking Generic Elavil (Amitriptyline HCl)

Interaction of Generic Elavil (Amitriptyline HCl) with Other Drugs

Side effects of Generic Elavil (Amitriptyline HCl)

Amitriptyline HCl is generic equivalent of Elavil, it is used for Relief of depression. Endogenous depression is more likely to be allevated than are other depressive states. Unlabeled use(s): Management of chronic pain associated with migraine, tension headache, phantom limb pain, tic douloureux, diabetic neuropathy, peripheral neuropathy, cancer or arthritis; treatment of panic and eating disorders.

What is Generic Elavil (Amitriptyline HCl)

Generic Elavil belong to calss Tricyclic antidepressant. Generic Elavil Inhibits presynaptic reuptake of norepinephrine and serotonin in CNS.

Generic Elavil (Amitriptyline HCl) Dosage or Administration

ADULTS: Titrate dosage over 2 wk to 1 mo. Give maintenance dose 6 mo to 1 yr. Do not interrupt therapy abruptly; reduce over 2 wk period. OUTPATIENTS: PO 75 to 150 mg/day in divided doses; give in evening or at bedtime because of sedative effects. HOSPITALIZED PATIENTS: PO 100 to 300 mg/day. ADOLESCENT & ELDERLY PATIENTS: PO 10 mg tid and 20 mg at bedtime. MAINTENANCE: PO 40 to 100 mg/day. PARENTERAL FORM: PO Do not use IV route. IM 20 to 30 mg qid. Change to oral dosing as soon as possible.

Precautions for Taking Generic Elavil (Amitriptyline HCl)

Pregnancy: Category D. Lactation: Excreted in breast milk. Children: Not recommended for children < 12 yr. Changing from MAO inhibitor to amitriptyline: Waiting period of 7 to 10 days is necessary to prevent hypertensive crisis. Special risk patients: Caution is needed with history of seizures; urinary retention; urethral or ureteral spasm; angle-closure glaucoma or increased IOP; cardiovascular disorders; hyperthyroidism and patients receiving thyroid medication; hepatic or renal impairment; schizophrenia; paranoia. Serotonin syndrome: Some TCAs inhibit neuronal reuptake of serotonin and can increase synaptic serotonin levels.

Interaction of Generic Elavil (Amitriptyline HCl) with Other Drugs

Barbiturates, charcoal: May cause decreased blood levels of amitriptyline. Cimetidine, fluoxetine: May cause increased blood levels of amitriptyline. Clonidine: Use with product may result in hypertensive crisis. CNS depressants: Depressant effects may be additive. MAOIs: May cause hyperpyretic crises, severe convulsions, and death when given with amitriptyline.

Side effects of Generic Elavil (Amitriptyline HCl)

CV: Orthostatic hypotension; hypertension; tachycardia; palpitations; arrhythmias; ECG changes. CNS: Confusion; hallucinations; disturbed concentration; decreased memory; delusions; nervousness; restlessness; agitation; panic; insomnia; nightmares; mania; exacerbation of psychosis; drowsiness; dizziness; weakness; emotional lability; numbness; tremors; extrapyramidal symptoms (eg, pseudoparkinsonism, movement disorders, akathisia); seizures. DERM: Rash; pruritus; photosensitivity reaction; dry skin; acne; itching. EENT: Conjunctivitis; blurred vision; increased IOP; mydriasis; tinnitus; nasal congestion; peculiar taste in mouth. GI: Nausea; vomiting; anorexia; GI distress; diarrhea; flatulence; dry mouth; constipation. GU: Impotence; sexual dysfunction; menstrual irregularities; dysmenorrhea; nocturia; urinary frequency; UTI; vaginitis; cystitis; urinary retention and hesitancy. HEMA: Bone marrow depression, including agranulocytosis; eosinophilia; purpura; thrombocytopenia; leukopenia. HEPA: Jaundice. META: Elevation or depression of blood sugar levels. RESP: Pharyngitis; rhinitis; sinusitis; cough. OTHER: Breast enlargement.
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