Information About Generic Desyrel (Trazodone HCl)

What is Generic Desyrel (Trazodone HCl)

Working of Generic Desyrel (Trazodone HCl)

Generic Desyrel (Trazodone HCl) Dosage or Administration

Precautions for Taking Generic Desyrel (Trazodone HCl)

Interaction of Generic Desyrel (Trazodone HCl) with Other Drugs

Side effects of Generic Desyrel (Trazodone HCl)

Trazodone HCl is generic equivalent of Desyrel, it is used for Treatment of depression. Unlabeled use(s): Treatment of neurogenic pain, aggression, panic disorder, cocaine withdrawal.

What is Generic Desyrel (Trazodone HCl)

Generic Desyrel belong to calss Antidepressant. Generic Desyrel affect serotonin uptake at presynaptic neuronal membrane.

Generic Desyrel (Trazodone HCl) Dosage or Administration

ADULTS: PO 150 mg/day in divided doses initially; increase in 50 mg increments up to maximum of 400 mg per day (outpatients) or 600 mg per day (inpatients). ELDERLY PATIENTS: PO Start with 75 mg/day in divided doses.

Precautions for Taking Generic Desyrel (Trazodone HCl)

Pregnancy: Category C. Lactation: Excreted in breast milk. Children: Safety and efficacy in children < 18 yr not established. Cardiac disease: Not recommended for patients in acute recovery from MI. Trazodone may also cause arrhythmias; patients with preexisting cardiac disease should be closely monitored. Lab tests: Patients who develop fever, sore throat or other signs of infection during therapy should have white blood cell count and differential taken, because trazodone may lower WBC and neutrophil counts. Priapism: Priapism (prolonged, painful inappropriate penile erection) has been reported. Condition may require surgical intervention. Any patient experiencing inappropriate or prolonged erection should stop taking trazodone immediately and notify physician. Suicide: Patients at risk should be closely monitored and not be given access to excessive quantities.

Interaction of Generic Desyrel (Trazodone HCl) with Other Drugs

Alcohol, barbituates, CNS depressants: CNS depressant effects may be additive. Carbamazepine: Plasma concentrations of trazodone and its active metabolite may be decreased, producing a decrease in therapeutic effect. Fluoxetine: May increase trazodone serum levels. Hypotensive agents: May cause additive hypotensive effects. MAO inhibitors: It is unknown whether interactions may take place. Initiate trazodone therapy cautiously if patient is currently taking or has recently stopped taking MAO inhibitors. Phenothiazines: Elevated trazodone serum concentrations have occurred, increasing the pharmacologic and toxic effects. SSRIs: A “serotonin syndrome,” including irritability, increased muscle tone, shivering, myoclonus, and altered consciousness may occur.

Side effects of Generic Desyrel (Trazodone HCl)

CV: Hypertension; orthostatic hypotension; shortness of breath; yncope; tachycardia; palpitations; chest pain; MI; arrhythmias; sinus bradycardia; onduction block; cardiac arrest; CHF; conduction block. CNS: Anger; hostility; nightmares/vivid dreams; confusion; disorientation; ecreased concentration; dizziness; drowsiness; excitement; fatigue; headache; nsomnia; impaired memory; nervousness; tingling; tremors; convulsions; incoordination; aresthesia; agitation; anxiety; grand mal seizures; hallucinations/delusions. EENT: Blurred vision; “red eyes;” ringing in ears; nasal or sinus congestion; tinnitus. GI: Abdominal/gastric disorders; unpleasant taste; dry mouth; nausea; vomiting; iarrhea; constipation; flatulence. GU: Altered libido; impotence; priapism; urinary retention; breast enlargement or engorgement; delayed urine flow; early menses. HEMA: Anemia; hemolytic anemia; decreased WBC. HEPA: Jaundice; increased LFTs. OTHER: Hypersensitivity reaction (eg, skin conditions, edema, rash, itching, purpura); muscle aches and pains; decreased appetite; sweating; changes in weight; malaise; allergic skin condition/edema; nasal/sinus congestion; akathisia; llergic reaction; alopecia; anemia; aphasia; apnea; ataxia; cardiac arrest; ardiospasm; cerebrovascular accident; chills; cholestatis; clitorism; diplopia; xtrapyramidal symptoms; hematuria; hemolytic anemia; hirsutism; hyperbilirubinemia.
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