Information About Generic Deltasone (Prednisolone)

What is Generic Deltasone (Prednisolone)

Working of Generic Deltasone (Prednisolone)

Generic Deltasone (Prednisolone) Dosage or Administration

Precautions for Taking Generic Deltasone (Prednisolone)

Interaction of Generic Deltasone (Prednisolone) with Other Drugs

Side effects of Generic Deltasone (Prednisolone)

Prednisolone is generic equivalent of Deltasone, it is used for Endocrine disorders: rheumatic disorders; collagen diseases; dermatologic diseases; allergic and inflammatory ophthalmic processes; respiratory diseases; hematologic disorders; neoplastic diseases; edematous states caused by nephrotic syndrome; GI diseases; multiple sclerosis; tuberculous meningitis; trichinosis with neurologic or myocardial involvement. Intra-articular or soft tissue administration: Short-term adjunctive therapy of synovitis of osteoarthritis, rheumatoid arthritis, bursitis, acute gouty arthritis, epicondylitis, acute nonspecific tenosynovitis, posttraumatic osteoarthritis. Intralesional administration: Treatment of the following lesions: keloids; localized hypertrophic, infiltrated, inflammatory lesions of lichen planus, psoriatic plaques, granuloma annulare, lichen simplex chronicus; discoid lupus erythematosus; necrobiosis lipoidica diabeticorum; alopecia areata; cystic tumors of aponeurosis or tendon. Ophthalmic administration: Treatment of steroid-responsive inflammatory conditions of palpebral and bulbar conjunctiva, lid, cornea and anterior segment of globe. Unlabeled use(s): Adjunctive therapy for tuberculous pleurisy.

What is Generic Deltasone (Prednisolone)

Generic Deltasone belong to calss Corticosteroid. Generic Deltasone Intermediate-acting glucocorticoid that depresses formation, release and activity of endogenous mediators of inflammation including prostaglandins, kinins, histamine, liposomal enzymes and complement system. Also modifies body's immune response.

Generic Deltasone (Prednisolone) Dosage or Administration

ADULTS: PO 5 to 60 mg/day (prednisolone, prednisolone sodium phosphate). IM 4 to 60 mg/day (prednisolone acetate). IV/IM 4 to 60 mg/day (prednisolone sodium phosphate). Ophthalmic 1 to 2 gtt into conjunctival sac q hr during day and q 2 hr during night (prednisolone acetate, prednisolone sodium phosphate).

Precautions for Taking Generic Deltasone (Prednisolone)

Pregnancy: Category C (prednisolone sodium phosphate). Safety not established. Lactation: Excreted in breast milk. Children: Observe growth and development of infants and children on prolonged therapy. Elderly: May require lower doses. Adrenal suppression: Prolonged therapy may lead to hypothalamic-pituitary-adrenal suppression. Cardiovascular effects: Use drug with great caution in patient who has suffered recent MI. Hepatitis: Drug may be harmful in patients with chronic active hepatitis positive for hepatitis B surface antigen. Hypersensitivity: Reactions may occur, including anaphylaxis. Immunosuppression: Do not administer live virus vaccines during treatment. Infections: Drug may mask signs of infection. May decrease host-defense mechanisms to prevent dissemination of infection. Ocular effects: Use systemic drug with caution in ocular herpes simplex because of possible corneal perforation. Ophthalmic use: Prolonged use may result in cataracts, glaucoma, or other complications. Peptic ulcer: May contribute to peptic ulceration, especially in large doses. Renal impairment: Use drug with caution. Repository injections: Do not inject SC. Avoid injection into deltoid muscle and repeated IM injection into same site. Stress: Increased dosage of rapidly acting corticosteroid may be needed before, during and after stressful situations. Withdrawal: Abrupt discontinuation may result in adrenal insufficiency.

Interaction of Generic Deltasone (Prednisolone) with Other Drugs

Anticholinesterases: May antagonize anticholinesterase effects in myasthenia gravis. Barbiturates: May decrease pharmacologic effect of prednisolone. Contraceptives (oral), estrogens, ketoconazole: May decrease clearance of prednisolone. Hydantoins, rifampin: May increase clearance and decrease efficacy of prednisolone. Salicylates: May reduce serum levels and efficacy of salicylates. Troleandomycin: May increase prednisolone effects.

Side effects of Generic Deltasone (Prednisolone)

CV: Thromboembolism or fat embolism; thrombophlebitis; necrotizing angiitis; cardiac arrhythmias or ECG changes; syncopal episodes; hypertension; myocardial rupture; CHF. CNS: Convulsions; pseudotumor cerebri (increased intracranial pressure with papilledema); vertigo; headache; neuritis; paresthesias; psychosis. DERM: Impaired wound healing; thin, fragile skin; petechiae and ecchymoses; erythema; lupus erythematosus–like lesions; subcutaneous fat atrophy; striae; hirsutism; acneiform eruptions; allergic dermatitis; urticaria; angioneurotic edema; perineal irritation; hyperpigmentation or hypopigmentation. EENT: Posterior subcapsular cataracts; increased intraocular pressure; glaucoma; exophthalmos. With ophthalmic use: glaucoma with optic nerve damage; visual acuity and field defects; posterior subcapsular cataract formation; secondary ocular infections; transient stinging or burning; perforation of globe. GI: Pancreatitis; abdominal distention; ulcerative esophagitis; nausea; vomiting; increased appetite and weight gain; peptic ulcer with perforation and hemorrhage; small and large bowel perforation. GU: Increased or decreased motility and number of spermatozoa. HEMA: Leukocytosis.
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