Information About Generic Coreg (Carvedilol)

What is Generic Coreg (Carvedilol)

Working of Generic Coreg (Carvedilol)

Generic Coreg (Carvedilol) Dosage or Administration

Precautions for Taking Generic Coreg (Carvedilol)

Interaction of Generic Coreg (Carvedilol) with Other Drugs

Side effects of Generic Coreg (Carvedilol)

Carvedilol is generic equivalent of Coreg, it is used for Management of essential hypertension; treatment of mild or moderate NYHA class II or III heart failure of ischemic or cardiomyopathic origin. Unlabeled uses: Angina pectoris; idiopathic cardiomyopathy.

What is Generic Coreg (Carvedilol)

Generic Coreg belong to calss Alpha-adrenergic blocker/Beta-adrenergic blocker. Generic Coreg Blocks alpha-1 receptors and nonselective beta-receptors to decrease BP.

Generic Coreg (Carvedilol) Dosage or Administration

ADULTS: PO Start with 6.25 mg bid, then if tolerated (based on standing BP about 1 hr after dosing), maintain the dose for 7 to 14 days; then increase to 12.5 mg bid, if tolerated, maintain the dose for 7 to 14 days; then increase to 25 mg bid (max 50 mg/day).

Precautions for Taking Generic Coreg (Carvedilol)

Pregnancy: Category C. Lactation: Undetermined. Children: Safety and efficacy not established. Elderly: Carvedilol plasma levels average 50% higher in elderly compared with young subjects; however, there were no notable differences in efficacy or adverse events. Anesthesia and major surgery: If carvedilol is continued perioperatively, use with caution with anesthetic agents that depress myocardial function (eg, ether). Bronchial asthma: Death in patients with status asthmaticus has occurred. Diabetes and hypoglycemia: May mask symptoms of hypoglycemia, particularly tachycardia; may potentiate insulin-induced hypoglycemia and delay recovery of serum glucose levels. Peripheral vascular disease: Because symptoms of arterial insufficiency may be aggravated or precipitated in patients with peripheral vascular disease, use with caution in such patients. Renal function impairment: May result in deterioration of renal function. Special risk patients: Use with caution in patients with pheochromocytoma, CHF, or Prinzmetal variant angina.

Interaction of Generic Coreg (Carvedilol) with Other Drugs

Antidiabetic agents (insulin and oral agents): Blood glucose-lowering effect may be enhanced. Calcium channel blockers (eg, diltiazem): Conduction disturbances may occur and BP may be altered. Catecholamine-depleting agents (eg, reserpine): Monitor for hypotension or severe bradycardia. Clonidine: Heart rate- and BP-lowering effects may be potentiated. Cyclosporine, digoxin: Plasma levels may be elevated by carvedilol, increasing the therapeutic and adverse effects. Inhibitors of CYP2D6 (eg, fluoxetine, paroxetine, propafenone, quinidine), poor metabolizers of debrisoquine: Expected to increase carvedilol blood levels.

Side effects of Generic Coreg (Carvedilol)

CV: Hypotension; postural hypotension; bradycardia; syncope; hypertension; AV block; aggravated angina pectoris; cardiac failure; palpitations; extrasystoles; angina; fluid overload; peripheral ischemia; tachycardia. CNS: Dizziness; headache; paresthesia; insomnia; somnolence; depression; hypesthesia; vertigo; malaise. DERM: Rash; pruritis; photosensitive reaction. EENT: Abnormal vision; sinusitis; pharyngitis; rhinitis; coughing. GI: Diarrhea; nausea; abdominal pain; vomiting; flatulence; anorexia; dyspepsia; melena; periodontitis. GU: UTI; hematuria; abnormal renal function; albuminuria; glucosuria; impotence. HEMA: Thrombocytopenia; anemia; decreased PT; purpura. HEPA: Hepatotoxicity; leukopenia. META: Hyperglycemia; weight increase; gout; BUN increase; nonprotein nitrogen increase; hypercholesterolemia; dehydration; hypervolemia; hypertriglyceridemia; hypoglycemia; hyponatremia; increased alkaline phosphatase; hyperkalemia; hypovolemia; glycosuria. RESP: Upper respiratory infection; bronchitis; dyspnea; respiratory disorder; asthma.
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