Information About Generic Cordarone (Amiodarone)

What is Generic Cordarone (Amiodarone)

Working of Generic Cordarone (Amiodarone)

Generic Cordarone (Amiodarone) Dosage or Administration

Precautions for Taking Generic Cordarone (Amiodarone)

Interaction of Generic Cordarone (Amiodarone) with Other Drugs

Side effects of Generic Cordarone (Amiodarone)

Amiodarone is generic equivalent of Cordarone, it is used for Treatment of life-threatening, recurrent ventricular arrhythmias (ie, ventricular fibrillation and hemodynamically unstable ventricular tachycardia) that do not respond to other antiarrhythmic agents. Use only in patients with the indicated life-threatening arrhythmias because its use is accompanied by substantial toxicity.

Parenteral

Initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation and hemodynamically unstable ventricular tachycardia in patients refractory to other therapy; treatment of ventricular tachycardia and fibrillation when oral amiodarone is indicated but patient is unable to take oral medication.

What is Generic Cordarone (Amiodarone)

Generic Cordarone belong to calss Antiarrhythmic. Generic Cordarone Prolongs action potential duration and refractory period in myocardial cells; acts as noncompetitive inhibitor of alpha- and beta-adrenergic receptors.

Generic Cordarone (Amiodarone) Dosage or Administration

Loading dose: PO 800 to 1600 mg/day for 1 to 3 wk. Reduce doses of other antiarrhythmic agents gradually. When adequate arrhythmia control is achieved, reduce dose to 600 to 800 mg/day for 1 mo.

Precautions for Taking Generic Cordarone (Amiodarone)

Pregnancy: Category D.

Lactation: Excreted in breast milk.

Children: Safety and efficacy not established.

Adult Respiratory Distress Syndrome (ARDS): ARDS has been reported.

Benzyl Alcohol: Benzyl alcohol, contained in some of these products as a preservative, has been associated with fatal “gasping syndrome” in children.

Ophthalmic Effects: Optic neuropathy or neuritis, resulting in visual impairment may occur.

Potential Fatal Toxicities: Pulmonary toxicity and arrhythmias have been reported.

Interaction of Generic Cordarone (Amiodarone) with Other Drugs

Anticoagulants: Effect of anticoagulant may be increased. Use of product may require 30% to 50% decrease in anticoagulant dose.

Beta-Blockers: Increased risk of hypotension and bradycardia as well as increased effect of beta blockers eliminated by hepatic metabolism.

Calcium Channel Blockers: Increased risk of atrioventricular block with verapamil or diltiazem as well as hypotension with other calcium blockers.

Cisapride, Disopyramide, Fluoroquinolones (eg, gatifloxacin, moxifloxacin, sparfloxacin): Possible prolongation of the QT interval, increasing the risk of life-threatening cardiac arrhythmias (including torsades de pointes).

Cholestyramine, Rifamycins (eg, rifampin): Amiodarone plasma levels may be reduced, decreasing the pharmacologic effect.

Cimetidine, Ritonavir: Amiodarone plasma levels may be elevated, increasing the risk of side effects.

Cyclosporine: Elevated plasma concentrations of cyclosporine resulting in elevated creatinine.

Dextromethorphan: Increased dextromethorphan plasma levels.

Digoxin: Serum digoxin levels may be increased.

Fentanyl: Increased risk of hypotension and bradycardia and decreased cardiac output.

Flecainide: Serum levels of flecainide may be increased.

Hydantoins (eg, phenytoin): Serum concentrations of hydantoins may be increased with potential for symptoms of hydantoin toxicity; also, amiodarone levels may be decreased.

Methotrexate, Theophylline: Amiodarone may elevate plasma levels of these agents, increasing the risk of toxicity.

Procainamide: Serum levels of procainamide may be increased.

Quinidine: Serum quinidine levels may increase, creating potential for fatal cardiac arrhythmias.

Side effects of Generic Cordarone (Amiodarone)

CARDIOVASCULAR: Exacerbation of arrhythmias, CHF, bradycardia, sinoatrial node dysfunction, heart block, sinus arrest, flushing (oral); hypotension, asystole/cardiac arrest, cardiogenic shock, ventricular tachycardia, atrioventricular block (parenteral). CNS: Fatigue; malaise; tremor/abnormal involuntary movements; lack of coordination; abnormal gait/ataxia; dizziness; paresthesias; decreased libido; insomnia; headache; sleep disturbances; abnormal sense of smell. DERMATOLOGIC: Photosensitivity, solar dermatitis, blue discoloration of skin (oral); Stevens-Johnson syndrome (parenteral). EENT: Visual disturbances; visual impairment; blindness; reversible asymptomatic corneal microdeposits; photophobia; abnormal taste. GI: Nausea, vomiting, constipation, anorexia, abdominal pain, abnormal salivation (oral); diarrhea (parenteral). HEMATOLOGIC: Coagulation abnormalities (oral); thrombocytopenia (parenteral). HEPATIC: Nonspecific hepatic disorders. RESPIRATORY: Pulmonary inflammation or fibrosis, progressive dyspnea, pulmonary toxicosis and death (oral); lung edema, respiratory disorder (parenteral). OTHER: Edema, hyperthyroidism or hypothyroidism (oral); fever (parenteral).
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