Information About Generic Celebrex (Celecoxib)

What is Generic Celebrex (Celecoxib)

Working of Generic Celebrex (Celecoxib)

Generic Celebrex (Celecoxib) Dosage or Administration

Precautions for Taking Generic Celebrex (Celecoxib)

Interaction of Generic Celebrex (Celecoxib) with Other Drugs

Side effects of Generic Celebrex (Celecoxib)

Celecoxib is generic equivalent of Celebrex, it is used to Relief of symptoms of osteoarthritis; relief of symptoms of rheumatoid arthritis in adults; management of acute pain in adults; treatment of primary dysmenorrhea; reduction of the number of adenomatous colorectal polyps in familial adenomatous polyposis (FAP), as an adjunct to usual care (eg, endoscopic surveillance, surgery).

What is Generic Celebrex (Celecoxib)

Generic Celebrex belong to calss COX-2 inhibitor. Generic Celebrex Reduces inflammation (eg, pain, redness, swelling, heat), fever, and pain by inhibiting chemicals in the body that cause inflammation, fever, and pain. This is probably caused by the inhibition of prostaglandin synthesis, primarily via inhibition of cyclooxygenase-2 (COX-2) isoenzyme.

Generic Celebrex (Celecoxib) Dosage or Administration

OSTEOARTHRITIS: ADULTS: PO 200 mg/day administered as a single dose or as 100 mg bid. Rheumatoid Arthritis: ADULTS: PO 100 to 200 mg bid. Acute Pain, Primary Dysmenorrhea: ADULTS: PO 400 mg initially followed by an additional 200 mg dose on day 1, if needed, then 200 mg twice daily as needed. FAP: ADULTS: PO Continue usual medical care for FAP patients while on celecoxib. To reduce the number of adenomatous colorectal polyps in patients with FAP, the recommended dose is 400 mg (2 × 200 mg capsules) bid. Take with food.

Precautions for Taking Generic Celebrex (Celecoxib)

Pregnancy: Category C. Lactation: Undetermined. Children: Safety and effectiveness in patients under 18 yr not established. Elderly: Initiate therapy with lowest recommended dose. Asthma: Use with caution in patients with pre-existing asthma. GI effects: Serious GI toxicity (eg, bleeding, ulcerations, perforations) can occur at any time, with or without warning symptoms.

Interaction of Generic Celebrex (Celecoxib) with Other Drugs

ACE Inhibitors: NSAIDs may diminish the antihypertensive effect of ACE inhibitors. Aspirin: Coadministration with celecoxib may result in an increased rate of GI ulceration or other complications. Fluconazole: Increase in celecoxib plasma concentration may occur because of inhibition of celecoxib metabolism. Furosemide: NSAIDs can reduce the natriuretic effect of furosemide and thiazides in some patients. Lithium: Mean steady-state lithium plasma levels increased about 17% in subjects receiving lithium with celecoxib. P450 2C9 Inhibitors: There is a potential for an in vivo drug interaction with drugs that are metabolized by P450 2D6. Warfarin: Monitor anticoagulant activity, particularly in the first few days, after initiating or changing celecoxib therapy in patients receiving warfarin or similar agents because these patients are at an increased risk of bleeding complications.

Side effects of Generic Celebrex (Celecoxib)

CARDIOVASCULAR: Aggravated hypertension; angina pectoris; coronary artery disorder; MI; palpitations; tachycardia. CNS: Dizziness; insomnia; fatigue; migraine; anxiety; anorexia; increased appetite; depression; nervousness; somnolence. DERMATOLOGIC: Rash; alopecia; dermatitis; nail disorder; photosensitivity; pruritus; erythematous rash; maculopapular rash; skin disorder; dry skin; increased sweating; urticaria; contact dermatitis; injection site reaction; skin nodule; cellulitis. EENT: Rhinitis; sinusitis; esophagitis; deafness; ear abnormality; earache; tinnitus; laryngitis; taste perversion; blurred vision; cataracts; conjunctivitis; eye pain; glaucoma. GI: Abdominal pain; diarrhea; dyspepsia; flatulence; constipation; diverticulitis; dysphagia; eructation; gastritis; gastroenteritis; gastroesophageal reflux; hemorrhoids; hiatal hernia; melena; dry mouth; stomatitis; tenesmus; tooth disorder; vomiting. GU: Breast fibroadenosis; breast neoplasm; breast pain; dysmenorrhea; menstrual disorder; vaginal hemorrhage; vaginitis; prostatic disorder; albuminuria; cystitis; dysuria; hematuria; micturition frequency; renal calculus; urinary incontinence; urinary tract infection.
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