Information About Generic Capoten (Captopril)

What is Generic Capoten (Captopril)

Working of Generic Capoten (Captopril)

Generic Capoten (Captopril) Dosage or Administration

Precautions for Taking Generic Capoten (Captopril)

Interaction of Generic Capoten (Captopril) with Other Drugs

Side effects of Generic Capoten (Captopril)

Captopril is generic equivalent of Capoten, it is used for Treatment of hypertension, CHF in patients unresponsive to or uncontrolled by conventional therapy, left ventricular dysfunction after MI, diabetic nephropathy. Unlabeled use(s): Treatment of hypertensive crisis, neonatal and childhood hypertension; rheumatoid arthritis; diagnosis of anatomic renal artery stenosis and primary aldosteronism; treatment of hypertension related to scleroderma renal crisis and Takayasu's disease; idiopathic edema; Bartter's and Raynaud's syndrome; asymptomatic left ventricular dysfunction after MI.

What is Generic Capoten (Captopril)

Generic Capoten belong to calss Antihypertensive/ACE inhibitor. Generic Capoten Competitively inhibits angiotensin I-converting enzyme, preventing conversion of angiotensin I to angiotension II, a potent vasoconstrictor that also stimulates aldosterone secretion. Results in decreased BP, potassium retention, and reduced sodium reabsorption.

Generic Capoten (Captopril) Dosage or Administration

Hypertension

ADULTS: Initial dose: PO 25 mg bid to tid; then gradually increase q 1 to 2 wk if satisfactory effect is not achieved. Usual dose: 25 to 150 mg bid to tid. Usual dose does not exceed 50 mg 3 times daily. Max daily dose is 450 mg.

Severe Hypertension

CHILDREN: PO 0.01–0.5 mg/kg/day.

Heart Failure

ADULTS: Initial dose: PO 6.25 to 12.5 mg tid; then titrate to usual daily dosage within next several days. Genereally to be used in conjunction with a diuretic and digitalis.

Left Ventricular Dysfunction after MI

ADULTS: PO 6.25 mg 3 days after MI; then 12.5 mg tid and 25 mg tid for next several days. Target dose: 50 mg tid over next several weeks.

Diabetic Nephropathy

ADULTS: PO 25 mg tid.

Precautions for Taking Generic Capoten (Captopril)

Pregnancy: Category D (second and third trimester); category C (first trimester). ACE inhibitors can cause injury or death to fetus if used during second or third trimester. When pregnancy is detected, discontinue ACE inhibitors as soon as possible. Lactation: Excreted in breast milk. Children: Safety and efficacy not established. Angioedema: Use with extreme caution in patients with hereditary angioedema. Hypotension/first-dose effect: Significant decreases in BP may occur after first dose, especially in patients with severe salt or volume depletion or those with CHF.

Interaction of Generic Capoten (Captopril) with Other Drugs

Allopurinol: Greater risk of hypersensitivity with coadministration. Antacids: May decrease bioavailability of captopril. Capsaicin: Cough may be exacerbated. Digoxin: Increased digoxin levels. Food: Reduces bioavailability of captopril. Indomethacin: Hypotensive effects may be reduced, especially in low-renin or volume-dependent hypertensive patients. Lithium: Increased lithium levels and symptoms of lithium toxicity may occur. Phenothiazines: May increase effect of captopril. Potassium preparations, potassium-sparing diuretics: May increase serum potassium levels. Probenecid: Increased captopril blood levels and decreased total clearance.

Side effects of Generic Capoten (Captopril)

CV: Chest pain; palpitations; tachycardia; orthostatic hypotension. CNS: Headache; sleep disturbances; paresthesias; dizziness; fatigue; malaise. DERM: Rash; pruritus; alopecia. EENT: Rhinitis. GI: Nausea; abdominal pain; vomiting; gastric irritation; aphthous ulcers; peptic ulcer; jaundice; cholestasis; diarrhea; dysgeusia; anorexia; constipation; dry mouth. GU: Oliguria; proteinuria. HEPA: Elevated liver enzymes and serum bilirubin. HEMA: Neutropenia; agranulocytosis; thrombocytopenia; pancytopenia. META: Hyperkalemia; hyponatremia; elevated uric acid and blood glucose. RESP: Chronic dry cough: dyspnea; eosinophilic pneumonitis. OTHER: Gynecomastia; myasthenia.
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