Information About Generic Calan SR (Verapamil)

What is Generic Calan SR (Verapamil)

Working of Generic Calan SR (Verapamil)

Generic Calan SR (Verapamil) Dosage or Administration

Precautions for Taking Generic Calan SR (Verapamil)

Interaction of Generic Calan SR (Verapamil) with Other Drugs

Side effects of Generic Calan SR (Verapamil)

canonical to calan

Verapamil is generic equivalent of Calan SR, it is used for Treatment of vasospastic (Prinzmetal's variant), chronic stable (classic effort-associated), and unstable (crescendo, preinfarction) angina; adjunctive treatment with digitalis to control ventricular rate at rest and during stress in atrial flutter or fibrillation; prophylaxis of repetitive paroxysmal supraventricular tachycardia (PSVT); management of essential hypertension. Sustained-release: Management of essential hypertension. Parenteral: Rapid conversion of PSVTs to sinus rhythm; temporary control of rapid ventricular rate in atrial flutter or fibrillation.

What is Generic Calan SR (Verapamil)

Generic Calan SR belong to calss Calcium channel blocker. Generic Calan SR Inhibits movement of calcium ions across cell membrane resulting in depression of mechanical contraction of myocardial and vascular smooth muscle and depression of impulse formation (automaticity) and conduction velocity.

Generic Calan SR (Verapamil) Dosage or Administration

ADULTS: PO 40 to 160 mg tid. Do not exceed 480 mg/day. Sustained release: PO 120 to 480 mg/day. Lower doses are given once daily; larger doses divided into 2 doses.

ADULTS: IV 5 to 10 mg bolus over 2 min. May repeat with 10 mg, 30 min after first dose. Give slower (over at least 3 min) in older patients.

CHILDREN 1 to 15 yr: IV 0.1 to 0.3 mg/kg (not to exceed 5 mg) over at least 2 min. May repeat in 30 min.

CHILDREN less than 1 yr: IV 0.1 to 0.2 mg/kg (usual range, 0.75 to 2 mg) bolus over 2 min with continuous ECG monitoring.

Precautions for Taking Generic Calan SR (Verapamil)

Pregnancy: Category C. Lactation: Excreted in breast milk. CHILDREN: Children less than 6 mo may not respond to IV use. Rare severe hemodynamic side effects have occurred in newborns and infants after IV use. ELDERLY: May have greater hypotensive effects in elderly. Elderly may respond to lower doses. Antiplatelet effects: Calcium channel blockers may inhibit platelet function. Cardiac conduction: May be associated with variety of cardiac conduction abnormalities including first-, second-, or third-degree AV block; bradycardia; asystole; severe hypotension; nodal escape rhythms; PR prolongation; and ventricular tachycardia in patients with atrial flutter/fibrillation and W-P-W syndrome caused by antegrade conduction.

Interaction of Generic Calan SR (Verapamil) with Other Drugs

Other antihypertensive agents: Additive hypotension. Beta blockers: May result in increased hypotension and adverse effects because of additive depressant effects on myocardial contractility or AV conduction. Buspirone: Pharmacologic and adverse effects may be increased by verapamil. Calcium salts: Clinical effects and toxicities of verapamil may be reversed. Carbamazepine: Increased carbamazepine serum levels. Cyclosporine: Increased cyclosporine levels may result. Dofetilide: Risk of life-threatening ventricular arrhythmias, including torsades de pointes, may be increased. Coadministration with verapamil is contraindicated. Digitalis glycosides: Increased serum digoxin or digitoxin levels may occur. Disopyramide: Do not use 48 hr before or 24 hr after verapamil. Flecainide: May prolong AV conduction. Nondepolarizing muscle relaxants: Enhanced muscle relaxant effects and prolonged respiratory depression may occur.

Side effects of Generic Calan SR (Verapamil)

CARDIOVASCULAR: Peripheral edema; hypotension; AV block; bradycardia; CHF; pulmonary edema; cerebrovascular accident. CNS: Dizziness; lightheadedness; headache; asthenia. DERMATOLOGIC: Dermatitis; rash; sweating; gingival hyperplasia. GI: Nausea; constipation. HEPATIC: Increased transaminases; hepatitis. RESPIRATORY: Shortness of breath; dyspnea; wheezing.
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