Information About Generic Biaxin (Clarithromycin)

What is Generic Biaxin (Clarithromycin)

Working of Generic Biaxin (Clarithromycin)

Generic Biaxin (Clarithromycin) Dosage or Administration

Precautions for Taking Generic Biaxin (Clarithromycin)

Interaction of Generic Biaxin (Clarithromycin) with Other Drugs

Side effects of Generic Biaxin (Clarithromycin)

Clarithromycin is generic equivalent of Biaxin, it is used for Treatment of infections of respiratory tract, skin and skin structure; treatment of disseminated atypical mycobacterial infections caused by susceptible strains of specific microorganisms. Prevention of disseminated Mycobacterium avium complex disease in patients with advanced HIV infection. Clarithromycin in combination with omeprazole is indicated for the treatment of patients with an active duodenal ulcer associated with Helicobacter pylori infection. CHILDREN: Acute otitis media.

What is Generic Biaxin (Clarithromycin)

Generic Biaxin belong to calss Antibiotic. Generic biaxin Inhibits microbial protein synthesis.

Generic Biaxin (Clarithromycin) Dosage or Administration

Acute Maxillary Sinusitis

ADULTS: PO Extended-release two 500 mg tablets q 24 hr for 14 days.

Acute exacerbation of chronic bronchitis caused by H. influenzae, H. parainfluenzae, M. catarrhalis, S. pheumoniae

ADULTS: PO Extended-release two 500 mg tablets q 24 hr for 7 days.

Community-acquired pneumonia caused by C. pneumoniae, H. influenzae, H. parainfluenzae, M. catarrhalis, S. pheumoniae

ADULTS: PO Extended-release two 500 mg tablets q 24 hr for 7 days. ADULTS AND CHILDREN ³ 12 yr: PO 250 to 500 mg q 12 hr for 7 to 14 days; use 500 mg q 12 hr for prevention and treatment of mycobacterial infections. CHILDREN: PO 7.5 mg/kg q 12 hr for 10 days. Maximum dose for treatment and prevention of mycobacterial infections is 500 mg bid.

Active Duodenal Ulcer Associated with H. pylori Infection

ADULTS: PO 500 mg clarithromycin and 40 mg omeprazole tid for days 1 to 14 and omeprazole 20 mg daily for days 15 to 28.

Precautions for Taking Generic Biaxin (Clarithromycin)

Pregnancy: Category C. Lactation: Undetermined. Other drugs of this class are excreted in breast milk. CHILDREN: Safety and efficacy in children < 6 mo not established. CHILDREN: Indicated for use in children only for mycobacterial infections; safety in children < 20 mo not established. Pseudomembranous Colitis: Consider possibility in patients in whom diarrhea develops. Renal or Hepatic Impairment: Use cautiously and adjust dose in patients with severe renal impairment. No dosage adjustment necessary if patient has impaired hepatic function but normal renal function.

Interaction of Generic Biaxin (Clarithromycin) with Other Drugs

Benxodiazepines Metabolized by Oxidation (eg, Midazolam): Increased and prolonged CNS effects. Buspirone, Cilostazol, Corticosteroids (eg, Methylprednisolone): Plasma levels of buspirone may be elevated, increasing the pharmacologic and adverse effects. Carbamazepine: May increase blood level concentrations of carbamazepine; recommend monitoring levels. Cisapride, Pimozide: Elevated plasma levels of cisapride and increased risk of serious cardiotoxicity, including arrhythmias and death. Cyclosporine: Elevated cyclosporine levels with increased risk of toxicity. Digoxin: Elevated serum digoxin levels. Ergot Derivatives (eg, Ergotamine): The risk of acute ergtism (eg, peripheral ischemia) may be increased. HMG-CoA Reductase Inhibitors (eg, Lovastatin): Increased risk of myopathy and rhabdomyolysis. Rifamycins (eg, Rifabutin): Antimicrobial effects of clarithromycin may be decreased, while adverse effect of rifamycins may be increased. Tacrolimus: Increased plasma levels with increased risk of toxicity. Theophylline: May increase theophylline plasma concentration; recommend monitoring levels. Warfarin: The anticoagulant effect may be increased, increasing the risk of hemorrhage.

Side effects of Generic Biaxin (Clarithromycin)

CARDIOVASCULAR: Ventricular arrhythmias. CNS: Headache; dizziness; insomnia; nightmares; vertigo. DERMATOLOGIC: Rash. EENT Hearing loss; tinnitus; abnormal sense of smell. GI: Diarrhea; nausea; vomiting; abnormal taste; dyspepsia; abdominal pain/discomfort; glossitis; stomatitis; oral moniliasis; vomiting. GU: Elevated BUN. HEMATOLOGIC: Elevated PT. HEPATIC: Hepatitis; jaundice. URTICARIA; hypersensitivity; anaphylaxis; Stevens-Johnson syndrome.
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