Information About Generic Benemid (Probenecid)

What is Generic Benemid (Probenecid)

Working of Generic Benemid (Probenecid)

Generic Benemid (Probenecid) Dosage or Administration

Precautions for Taking Generic Benemid (Probenecid)

Interaction of Generic Benemid (Probenecid) with Other Drugs

Side effects of Generic Benemid (Probenecid)

Probenecid is generic equivalent of Benemid, it is used for Treatment of hyperuricemia associated with gout and gouty arthritis; adjunctive therapy with penicillins or cephalosporins to elevate and prolong serum levels.

What is Generic Benemid (Probenecid)

Generic Benemid belong to calss Analgesic/Gout/Uricosuric. Generic Benemid Inhibits tubular reabsorption of urate, thus increasing urinary excretion of uric acid. Inhibits tubular secretion of most penicillin and cephalosporin antibiotics.

Generic Benemid (Probenecid) Dosage or Administration

Gout

ADULTS & CHILDREN > 110 LB: PO 250 mg bid initially (for 1 wk), followed by 500 mg bid. Maintenance: May reduce by 500 mg q 6 mo until serum uric acid increases.

In Conjunction with Antibiotic Therapy: PO 2 g/day in divided doses. CHILDREN 2 to 14 YR (< 110 LB): PO 25 mg/kg or 0.7 g/m2 initially. Maintenance: 40 mg/kg/day or 1.2 g/m2, divided into 4 doses.

Precautions for Taking Generic Benemid (Probenecid)

Pregnancy: Pregnancy category undetermined. Probenecid crosses placenta and appears in cord blood. Children: Not recommended for children < 2 yr. Alkalinization of urine: May be needed to prevent hematuria, renal colic, costovertebral pain, formation of uric acid stones. Exacerbation of gout: May occur; appropriate drug therapy (eg, colchicine or other appropriate therapy) is advisable. History of peptic ulcer: Use with caution. Hypersensitivity: Severe allergic reactions and anaphylaxis, although rare, have occurred. These have usually been associated with prior probenecid use. Renal impairment: May require increased doses for gout (not to exceed 2 g/day). Probenecid may be ineffective in chronic renal insufficiency (ie, glomerular filtration rate of < 30 ml/min). Drug is not recommended for use with penicillin in cases of known renal impairment.

Interaction of Generic Benemid (Probenecid) with Other Drugs

Interacts with many other drugs by altering their clearance and elimination.

Barbiturate anesthetics, dyphylline, methotrexate, oral hypoglycemic agents, zidovudine: Increased serum levels and effects of these drugs. Salicylates: Inhibition of uricosuric effect of either drug.

Side effects of Generic Benemid (Probenecid)

CNS: Headaches; dizziness. DERM: Dermatitis; pruritus. GI: Anorexia; nausea; GI distress; vomiting; sore gums. GU: Urinary frequency; hematuria; renal colic; nephrotic syndrome. HEMA: Anemia; hemolytic anemia (possibly related to G-6-PD deficiency); aplastic anemia. HEPA: Hepatic necrosis. OTHER: Hypersensitivity reactions; anaphylaxis; fever; flushing; exacerbation of gout; uric acid stones; costovertebral pain.
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