Information About Generic Artane (Trihexyphenidyl)

What is Generic Artane (Trihexyphenidyl)

Working of Generic Artane (Trihexyphenidyl)

Generic Artane (Trihexyphenidyl) Dosage or Administration

Precautions for Taking Generic Artane (Trihexyphenidyl)

Interaction of Generic Artane (Trihexyphenidyl) with Other Drugs

Side effects of Generic Artane (Trihexyphenidyl)

Trihexyphenidyl is generic equivalent of Artane, it is used for Adjunct in treatment of all forms of parkinsonism (postencephalitic, arteriosclerotic and idiopathic); adjuvant therapy with levodopa for control of drug-induced extra-pyramidal disorders. Sustained release: Maintenance therapy after patients have been stabilized on tablets or elixir.

What is Generic Artane (Trihexyphenidyl)

Generic Artane belong to calss Antiparkinson/anticholinergic. Generic Trihexyphenidyl Exerts direct inhibitory effect on parasympathetic nervous system by inhibiting actions of acetylcholine; has relaxing effect on smooth musculature.

Generic Artane (Trihexyphenidyl) Dosage or Administration

Parkinsonism

ADULTS: PO 1 or 2 mg first day; increase by 3 mg increments at intervals of 3–5 days, until 6–10 mg given daily in divided doses. Some postencephalitic patients may require total daily dose of 12–15 mg. Usually given tid at mealtimes. High doses may be taken qid, at mealtimes and at bedtime.

Concomitant Use with Other Anticholinergics

Gradually initiate trihexyphenidyl with progressive reduction of other anticholinergic.

Drug-Induced Extrapyramidal Disorders

Amount and frequency is individualized. Start with single 1 mg dose. If symptoms are not controlled in few hours, progressively increase until controlled. Daily dosage usually ranges 5–15 mg in divided doses.

Sustained Release

Not for initial therapy. Once patient is stabilized, may switch on equipotent daily basis. Give as single dose after breakfast or in bid doses 12 hr apart.

Precautions for Taking Generic Artane (Trihexyphenidyl)

Pregnancy: Category C. Lactation: Undetermined. Children: Safety and efficacy not established. Elderly patients: More susceptible to adverse effects. Special risk patients: Use drug with caution in patients with tachycardia, arrhythmias, hypertension, hypotension, prostatic hypertrophy, liver or kidney disorders, obstructive disease of GI tract. Anticholinergic effect: Concomitant use of other drugs with anticholinergic effects will have additive effects. Heat illness: Give with caution during hot weather. Severe anhidrosis and fatal hyperthermia may occur. Ophthalmic: Incipient narrow-angle glaucoma may be precipitated by drug use; therefore closely monitor patient for symptoms and evaluate intraocular pressure at regular, periodic intervals.

Interaction of Generic Artane (Trihexyphenidyl) with Other Drugs

Haloperidol: Schizophrenic symptoms may worsen; haloperidol levels may decrease and tardive dyskinesia may develop. Phenothiazines: Actions of phenothiazines may be decreased.

Side effects of Generic Artane (Trihexyphenidyl)

CV: Tachycardia; palpitations; hypotension. CNS: Dizziness; nervousness; psychiatric manifestations such as delusions or hallucinations; mental confusion; agitation; disturbed behavior. DERM: Rash. EENT: Blurred vision; angle-closure glaucoma; difficulty swallowing. GI: Dry mouth; nausea; vomiting; constipation; suppurative parotitis; dilation of colon; paralytic ileus. GU: Urinary retention; urinary hesitancy; impotence. OTHER: Fever; flushing; decreased sweating; heat illness. generic viagra