Information About Generic Antabuse (Disulfiram)

What is Generic Antabuse (Disulfiram)

Working of Generic Antabuse (Disulfiram)

Generic Antabuse (Disulfiram) Dosage or Administration

Precautions for Taking Generic Antabuse (Disulfiram)

Interaction of Generic Antabuse (Disulfiram) with Other Drugs

Side effects of Generic Antabuse (Disulfiram)

Disulfiram is generic equivalent of Antabuse, it is used for Aid in management of alcoholism in selected patients who want to remain in state of enforced sobriety.

What is Generic Antabuse (Disulfiram)

Generic Antabuse belong to calss Antialcoholic. Generic Disulfiram Aid in management of alcoholism in selected patients who want to remain in state of enforced sobriety.

Generic Antabuse (Disulfiram) Dosage or Administration

ADULTS: PO 500 mg qd (single dose) initially for 1 to 2 wk. Maintenance dose: PO 125 to 500 mg qd (maximum 500 mg/day).

Precautions for Taking Generic Antabuse (Disulfiram)

Pregnancy: Undetermined. Lactation: Undetermined. Special risk patients: Use with caution in patients with diabetes mellitus, hypothyroidism, epilepsy, cerebral damage, chronic and acute nephritis and hepatic cirrhosis or insufficiency. Disulfiram-alcohol reaction: Avoid alcohol in all forms, including alcoholic beverages, vinegars, liquid medications such as cough syrups or tonic, some sauces and aftershave products. Do not give disulfiram within 12 hr of drinking alcohol. Reactions can occur up to 2 wk after discontinuing disulfiram. Ethylene dibromide: Patients receiving disulfiram should not be exposed to ethylene dibromide or its vapors; toxic interaction resulting in tumors and death has occurred in research animals. Hypersensitivity. Evaluate patients with history of rubber contact dermatitis for hypersensitivity to thiuram derivatives. Intoxication: Never give drug to intoxicated patient or without patient's knowledge.

Interaction of Generic Antabuse (Disulfiram) with Other Drugs

Alcohol: Causes severe alcohol-intolerance reaction. Symptoms include flushing, throbbing in head and neck, respiratory difficulty, nausea, vomiting, sweating, thirst, chest pain, palpitations, shortness of breath, tachycardia, hypotension, syncope, weakness, vertigo, blurred vision and confusion. In severe reactions there may be respiratory depression, cardiovascular collapse, unconsciousness, convulsions and death. Anticoagulants: Disulfiram may increase anticoagulant effect. Antidepressants, tricyclic: May produce acute organic brain syndrome. Benzodiazepines: Disulfiram decreases plasma clearance of benzodiazepines metabolized by oxidation. Hydantoins: Disulfiram may increase serum hydantoin levels. Isoniazid: Acute behavioral and coordination changes. Metronidazole: May cause patients to exhibit acute toxic psychosis or confusional state. One or both agents may need to be discontinued. Theophyllines: Disulfiram may inhibit metabolism and increase effect of theophyllines.

Side effects of Generic Antabuse (Disulfiram)

CNS: Drowsiness; fatigue; headache; depression; restlessness; psychotic reactions. DERM: Skin eruptions. EENT: Metallic or garlic-like aftertaste. HEPA Hepatotoxicity; hepatitis. OTHER: Peripheral neuropathy; polyneuritis; optic or retrobulbar neuritis; arthropathy; impotence. generic viagra