Information About Generic Amaryl (Glimepiride)

What is Generic Amaryl (Glimepiride)

Working of Generic Amaryl (Glimepiride)

Generic Amaryl (Glimepiride) Dosage or Administration

Precautions for Taking Generic Amaryl (Glimepiride)

Interaction of Generic Amaryl (Glimepiride) with Other Drugs

Side effects of Generic Amaryl (Glimepiride)

Glimepiride is generic equivalent of Amaryl, it is used for Adjunct to diet and exercise in type II diabetics whose hyperglycemia cannot be controlled by diet and exercise alone; in combination with insulin for type II diabetics with secondary failure to oral sulfonylureas.

What is Generic Amaryl (Glimepiride)

Generic Amaryl belong to calss Antidiabetic/Sulfonylurea. Generic Glimepiride Decreases blood glucose by stimulating insulin release from pancreas. May also decrease hepatic glucose production as well as increase sensitivity to insulin.

Generic Amaryl (Glimepiride) Dosage or Administration

ADULTS: PO 1 to 2 mg qd with breakfast or the first main meal of the day. Increase by 1 to 2 mg/dose. Titrate at 1 to 2 week intervals based on blood glucose response. Maintenance: 1 and 4 mg daily (maximum 8 mg/day). Combination therapy with insulin is appropriate for secondary failure to oral sulfonylureas. The same dosing recommendations apply.

Precautions for Taking Generic Amaryl (Glimepiride)

Pregnancy: Category C. Insulin is recommended to maintain blood glucose levels during pregnancy. Prolonged severe neonatal hypoglycemia can occur if sulfonylureas are administered at time of delivery. Lactation: Undetermined. Children: Safety and efficacy not established. Elderly and debilitated patients: Increased risk for development of hypoglycemia. Hypoglycemia may be difficult to detect in elderly patients. Hepatic and renal impairment: Use with caution; lower doses may be adequate.

Interaction of Generic Amaryl (Glimepiride) with Other Drugs

Alcohol: Produces disulfiram-like reaction (facial flushing, headache, breathlessness). Chloramphenicol, clofibrate, fenfluramine, histamine H2 antagonists, miconazole, monoamine oxidase inhibitors, probenecid, salicylates, sulfinpyrazone, sulfonamides, tricyclic antidepressants, urinary acidifiers: May increase hypoglycemic effect. Betablockers, cholestyramine, diazoxide, rifampin, thiazide diuretics, urinary alkalinizers: May decrease hypoglycemic effect.

Side effects of Generic Amaryl (Glimepiride)

CV: Although issue is controversial, oral sulfonylureas may have increased risk of cardiovascular morbidity when compared with patients treated with diet alone. CNS: Dizziness. DERM: Allergic skin reactions (pruritus, erythema, urticaria, morbilliform or maculopapular rash); porphyria cutanea tarda; photosensitivity. EENT: Blurred vision. GI: Nausea; vomiting; gastrointestinal pain; diarrhea. HEMA: Leukopenia; agranulocytosis; thrombocytopenia; hemolytic anemia; aplastic anemia; pancytopenia. HEPA: Cholestatic jaundice; elevated liver function tests. META: Hypoglycemia. OTHER: Headache; asthenia; hyponatremia with or without syndrome of inappropriate antidiuretic hormone (SIADH).