Information About Generic Aldactone (Spironolactone)

What is Generic Aldactone (Spironolactone)

Working of Generic Aldactone (Spironolactone)

Generic Aldactone (Spironolactone) Dosage or Administration

Precautions for Taking Generic Aldactone (Spironolactone)

Interaction of Generic Aldactone (Spironolactone) with Other Drugs

Side effects of Generic Aldactone (Spironolactone)

Spironolactone is generic equivalent of Aldactone, it is used for Short-term preoperative treatment of primary hyperaldosteronism; long-term maintenance therapy for idiopathic hyperaldosteronism; management of edematous conditions in CHF, cirrhosis of liver and nephrotic syndrome; management of essential hypertension; treatment of hypokalemia. Unlabeled use(s): Treatment of hirsutism; relief of PMS symptoms; short-term treatment of familial male precocious puberty; and short-term treatment of acne vulgaris.

What is Generic Aldactone (Spironolactone)

Generic Aldactone belong to calss Potassium-sparing diuretic. Generic Spironolactone Competitively inhibits aldosterone in distal tubules, resulting in increased excretion of sodium and water and decreased excretion of potassium.

Generic Aldactone (Spironolactone) Dosage or Administration

Diagnosis of Primary Hyperaldosteronism

ADULTS: PO 400 mg/day for 4 days (short test) or 3 to 4 wk (long test).

Maintenance Therapy for Hyperaldosteronism

ADULTS: PO 100 to 400 mg daily in single or divided doses.

Edema

ADULTS: PO 25 to 200 mg/day in single or divided doses. CHILDREN: PO 3.3 mg/kg/day in single or divided doses.

Essential Hypertension

ADULTS: PO 50 to 100 mg/day in single or divided doses. CHILDREN: PO 1 to 2 mg/kg bid.

Diuretic-Induced Hypokalemia

ADULTS: PO 25 to 100 mg/day when oral potassium or other potassium-sparing regimens are inappropriate.

Precautions for Taking Generic Aldactone (Spironolactone)

Pregnancy: Category D. Lactation: Excreted in breast milk. Electrolyte imbalances and BUN increase: Hyperkalemia (serum potassium > 5.5 mEq/L), hyponatremia, hypochloremia and increases in BUN may occur.

Interaction of Generic Aldactone (Spironolactone) with Other Drugs

ACE inhibitors: May result in severely elevated serum potassium levels. Digitalis glycosides: May decrease digoxin clearance, resulting in increased serum digoxin levels and toxicity; may attenuate inotropic action of digoxin. Mitotane: May decrease therapeutic response to mitotane. Potassium preparations: May severely increase serum potassium levels, possibly resulting in cardiac arrhythmias or cardiac arrest. Do not take with potassium preparations. Salicylates: May result in decreased diuretic effect.

Side effects of Generic Aldactone (Spironolactone)

CNS: Drowsiness; lethargy; headache; mental confusion; ataxia. DERM: Maculopapular or erythematous cutaneous eruptions; urticaria. GI: Cramping; diarrhea; gastric bleeding; gastric ulceration; gastritis; vomiting. GU: Inability to achieve or maintain erection. HEMA: Agranulocytosis. META: Hyperchloremic metabolic acidosis in decompensated hepatic cirrhosis. OTHER: Gynecomastia; irregular menses or amenorrhea; postmenopausal bleeding; hirsutism; deepening of voice; drug fever; carcinoma of breast.
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