Information About Generic Adalat (Nifedipine)

What is Generic Adalat (Nifedipine)

Working of Generic Adalat (Nifedipine)

Generic Adalat (Nifedipine) Dosage or Administration

Precautions for Taking Generic Adalat (Nifedipine)

Interaction of Generic Adalat (Nifedipine) with Other Drugs

Side effects of Generic Adalat (Nifedipine)

Nifedipine is generic equivalent of Adalat, it is used to treat vasospastic (Prinzmetal's or variant) angina, chronic stable angina, hypertension (sustained-release tablets only).

What is Generic Adalat (Nifedipine)

Generic Adalat belong to calss Calcium channel blocker. Generic Nifedipine Inhibits movement of calcium ions across cell membrane in systemic and coronary vascular smooth muscle and myocardium. Increases CO and decreases peripheral vascular resistance. Minimal effect on sinoatrial and AV nodal conduction. Reduces myocardial oxygen demand; relaxes and prevents coronary artery spasm.

Generic Adalat (Nifedipine) Dosage or Administration

Capsules: ADULTS: PO 10 mg tid (usual dose range, 10 to 20 mg tid); swallow whole. Some patients (eg, coronary artery spasm) respond only to higher doses administered more frequently (eg, 20 to 30 mg tid to qid; max 180 mg/day). In hospitalized patients, under close observation, dose may be increased in 10 mg increments throughout 4- to 6-hr periods as required to control pain and arrhythmias caused by ischemia. A single dose rarely exceeds 30 mg. Extended-release tablets: ADULTS: PO Procardia XL and Nifedical XL: 30 or 60 mg once daily, titrated over 7- to 14-day period (max, 120 mg/day). Adalat CC (hypertension): Start with 30 mg/day and titrate dose over 7- to 14-day period (max, 90 mg/day).

Precautions for Taking Generic Adalat (Nifedipine)

Pregnancy: Category C. Lactation: Excreted in breast milk in small amounts. CHILDREN: Safety and efficacy not established. ELDERLY: May experience greater hypotensive effects. Acute hepatic injury: In rare instances, nifedipine has been associated with significant elevations in liver enzymes, symptoms consistent with acute hepatic injury, cholestasis with or without jaundice and allergic hepatitis. Antiplatelet effects: Nifedipine decreases platelet aggregation and can increase bleeding time in some patients. Beta-blocker withdrawal: Patients withdrawn from beta-blockers while taking nifedipine may experience increased angina. CHF: Use drug with caution in patients with CHF. Edema: Nifedipine has been associated with edema in some cases and should be distinguished from fluid retention secondary to heart failure. Hepatic impairment: Use drug with caution in patients with impaired hepatic function, reduced hepatic blood flow, or hepatic cirrhosis. Increased angina: Occasional patients may have increased frequency, duration, or severity of angina at start of therapy or when dose is increased. Withdrawal: Abrupt withdrawal may cause increased frequency and duration of angina.

Interaction of Generic Adalat (Nifedipine) with Other Drugs

Barbiturates, rifampin: May reduce nifedipine levels, decreasing the therapeutic effect. Cimetidine: May increase bioavailability of nifedipine. Cisapride, diltiazem: May elevate nifedipine levels, increasing the risk of side effects. Fentanyl, parenteral magnesium: Hypotension may occur. Melatonin: May interfere with the antihypertensive effects of nifedipine. Tacrolimus: Tacrolimus trough concentrations may be elevated, increasing the risk of toxicity. Other hypertensive agents: May have additive effects.

Side effects of Generic Adalat (Nifedipine)

CARDIOVASCULAR: Peripheral edema; hypotension; palpitations; syncope; CHF; MI; arrhythmia; pulmonary edema; angina; tachycardia. CNS: Dizziness; lightheadedness; giddiness; nervousness; headache; sleep disturbances; insomnia; abnormal dreams; blurred vision; equilibrium disturbances; weakness; jitteriness; paresthesia; somnolence; malaise; anxiety. DERMATOLOGIC: Dermatitis; rash; pruritus; urticaria; Stevens-Johnson syndrome. EENT: Tinnitus; sinusitis; rhinitis. GI: Nausea; diarrhea; constipation; abdominal discomfort; cramps; dyspepsia; dry mouth; flatulence. GU: Micturition disorders; sexual difficulties. HEPATIC: Hepatitis; hepatotoxicity; elevations of LFT enzymes. HEMATOLOGIC: Anemia; leukopenia; thrombocytopenia; bruising; positive Coombs' test with or without hemolytic anemia. RESPIRATORY: Nasal or chest congestion; shortness of breath; wheezing; cough; respiratory infection. OTHER: Flushing; gingival hyperplasia; sweating; muscle cramps, pain and inflammation; joint stiffness, pain, or arthritis; chills; fever; thirst.

Adalat
Capsules: 10 mg
Capsules: 20 mg
Adalat CC
Tablets, extended-release: 30 mg
Tablets, extended-release: 60 mg
Tablets, extended-release: 90 mg
Nifedical XL
Tablets, extended-release: 30 mg
Tablets, extended-release: 60 mg
Procardia
Capsules: 10 mg
Capsules: 20 mg
Procardia XL
Tablets, extended-release: 30 mg
Tablets, extended-release: 60 mg
Tablets, extended-release: 90 mg
Adalat PA
Adalat PA 10
Adalat PA 20
Adalat XL
Apo-Nifed
Apo-Nifed PA
Gen-Nifedipine
Novo-Nifedin
Nu-Nifed
Taro-Nifedipine
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