Information About Generic Accupril (Quinapril HCl)

What is Generic Accupril (Quinapril HCl)

Working of Generic Accupril (Quinapril HCl)

Generic Accupril (Quinapril HCl) Dosage or Administration

Precautions for Taking Generic Accupril (Quinapril HCl)

Interaction of Generic Accupril (Quinapril HCl) with Other Drugs

Side effects of Generic Accupril (Quinapril HCl)

Generic equivalent of Accupril is used to treat Indications Treatment of hypertension; adjunctive therapy of CHF.

What is Generic Accupril (Quinapril HCl)

Class: Antihypertensive/angiotensin-converting enzyme (ACE) inhibitor

Action Competitively inhibits angiotensin I–converting enzyme, resulting in prevention of angiotensin I conversion to angiotensin II, a potent vasoconstrictor that also stimulates aldosterone release. Clinical consequences are decrease in BP, reduced sodium resorption, and potassium retention.

Generic Accupril (Quinapril HCl) Dosage or Administration

Hypertension

ADULTS: PO 10 or 20 mg qd initially; adjust dosage at intervals of ³ 2 weeks. Maintenance: 20, 40, or 80 mg/day as single dose or 2 equally divided doses. In presence of renal impairment, recommended initial dose varies based on creatinine clearance: > 60 ml/min = 10 mg; 30 to 60 ml/min = 5 mg; 10 to 30 ml/min = 2.5 mg. ELDERLY: PO 10 mg qd followed by titration to the optimal response.

Precautions for Taking Generic Accupril (Quinapril HCl)

Pregnancy: Category D (second, third trimester); Category C (first trimester). Avoid use in pregnant patients and discontinue drug as soon as pregnancy is detected; closely observe infants with histories of in utero exposure. Lactation: Undetermined. Children: Safety and efficacy not established. Elderly patients: May show higher peak blood levels of metabolite. Angioedema: May occur and is potentially fatal if laryngeal edema occurs. Use drug with extreme caution in patients with hereditary angioedema. Cough: Chronic cough may occur during treatment; more common in women. Hepatic impairment: Use drug with caution; dosage reduction may be necessary because of impaired metabolism. Hypotension/first-dose effect: Significant decreases in BP may occur after first dose, especially in severely salt- or volume-depleted patients (eg, patients on aggressive diuretic therapy) or in those with heart failure. Neutropenia and agranulocytosis: Have occurred rarely; risk appears greater with renal dysfunction, heart failure, or immunosuppression. Proteinuria: Has occurred with similar agents, especially with high doses or prior renal disease. Renal impairment: May further decrease renal function with elevations in BUN and serum creatinine because of decreased renal perfusion. Furthermore, dosage should be reduced to compensate for reduced drug elimination.

Interaction of Generic Accupril (Quinapril HCl) with Other Drugs

Allopurinol: Greater risk of hypersensitivity possible with coadministration. Antacids: Quinapril bioavailability may be decreased. Separate administration times by 1 to 2 hr. Capsaicin: Cough may be exacerbated. Digoxin: May cause increased digoxin levels. Diuretics: Increased risk of hypotension. Food: Food (especially fat) reduces bioavailability of quinapril. Indomethacin: May reduce hypotensive effects, especially in low renin or volume-dependent hypertensive patients. Lithium: May cause increased lithium levels and symptoms of lithium toxicity. Loop diuretics: Effects of loop diuretics may be decreased. Phenothiazines: Enhanced hypotensive effect. Potassium supplements and potassium-sparing diuretics: Hyperkalemia. Tetracycline: Decreased tetracycline absorption.

Side effects of Generic Accupril (Quinapril HCl)

CV: Hypotension; orthostatic hypotension. CNS: Headache; dizziness; fatigue; nervousness. DERM: Pruritus. GI: Nausea; abdominal pain; vomiting; diarrhea. META: Hyperkalemia; hyponatremia. RESP: Cough; asthma; bronchospasm. OTHER: Hypersensitivity; angioedema.